5,6-Dichloropyridin-3-ol

Base Information

• Chemical Name: 5,6-Dichloropyridin-3-ol
• CAS No.: 110860-92-9
• Molecular Formula: C5H3Cl2NO
• Molecular Weight: 163.991
• Hs Code.: 2933399090
• European Community (EC) Number: 833-803-7
• DSSTox Substance ID: DTXSID00559765
• Nikkaji Number: J323.948I
• Wikidata: Q72466438
• Mol file: 110860-92-9.mol

Synonyms:5,6-Dichloropyridin-3-ol;2,3-Dichloro-5-hydroxypyridine;110860-92-9;5,6-dichloro-3-pyridinol;MFCD09835219;5,6-dichloro-3-hydroxypyridine;5,6-dichloro-pyridin-3-ol;3-Pyridinol, 5,6-dichloro-;SCHEMBL314919;AMY7934;DTXSID00559765;GMHPKIGFTDRQBP-UHFFFAOYSA-N;5 pound not6-Dichloropyridin-3-ol;AKOS006327894;CS-W003660;SB13147;DS-14388;SY022519;D4899;EN300-179790;A802256;W-200826

Chemical Property of 5,6-Dichloropyridin-3-ol

Chemical Property:

• Vapor Pressure: 7.45E-06mmHg at 25°C
• Melting Point: 184.0 to 188.0 °C
• Refractive Index: 1.602
• Boiling Point: 365.5 °C at 760 mmHg
• PKA: 7.91±0.10(Predicted)
• Flash Point: 174.8 °C
• PSA: 33.12000
• Density: 1.561 g/cm³
• LogP: 2.09400
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 162.9591691
• Heavy Atom Count: 9
• Complexity: 101

Purity/Quality:

99% ^*data from raw suppliers

5,6-Dichloropyridin-3-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=NC(=C1Cl)Cl)O

Technology Process of 5,6-Dichloropyridin-3-ol

There total 7 articles about 5,6-Dichloropyridin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ 5.6-Dichloro-3-hydroxypyridine (110860-92-9)

Guidance literature:

With dihydrogen peroxide; In tetrahydrofuran; water; at 20 ℃; for 4h;

Reference yield: 96.0%

5-acetoxy-2,3-dichloropyridine (110861-18-2) → 5.6-Dichloro-3-hydroxypyridine (110860-92-9)

Guidance literature:

With potassium hydroxide; at 5 ℃; for 0.5h;

DOI:10.1055/s-1990-26919

Reference yield:

5-Amino-2,3-dichloropyridine (98121-41-6) → 5.6-Dichloro-3-hydroxypyridine (110860-92-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) HBF₄, NaNO₂ / 1) water, 0 deg C, 1 h, 2) 70 deg C, 1h

2: 96 percent / 2 N KOH / 0.5 h / 5 °C

With potassium hydroxide; tetrafluoroboric acid; sodium nitrite;

DOI:10.1055/s-1990-26919

upstream raw materials:

5-chloropyridin-3-ol

5-acetoxy-2,3-dichloropyridine

5-nitro-2-hydroxypyridine

2,3-dichloro-5-nitropyridine

Downstream raw materials:

((5,6-dichloro-2-cyanopyridin-3-yl)oxy)acetic acid ethyl ester

Refernces

• 1、 -. "N-SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF". Paragraph 0316-0317; 0320-0321. . Retrieved 2014/01/18.
• 2、 -. "Substituted 2-phenylpyridines as herbicides". . . Retrieved 2008/06/13.