D-Cyclohexylalanine hydrochloride

Base Information

• Chemical Name: D-Cyclohexylalanine hydrochloride
• CAS No.: 99065-30-2
• Molecular Formula: C9H17NO2.HCl
• Molecular Weight: 207.7
• Hs Code.: 2922499990
• Mol file: 99065-30-2.mol

Synonyms:Cyclohexanealanine,hydrochloride (6CI);Cyclohexanepropanoic acid, a-amino-, hydrochloride (9CI);

Chemical Property of D-Cyclohexylalanine hydrochloride

Chemical Property:

• Melting Point: 259℃ (DEC.)
• Boiling Point: 307.1 °C at 760 mmHg
• Flash Point: 139.6 °C
• PSA: 63.32000
• LogP: 2.87100

Purity/Quality:

98%Min ^*data from raw suppliers

2-amino-3-cyclohexylpropanoicAcidhydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of D-Cyclohexylalanine hydrochloride

There total 2 articles about D-Cyclohexylalanine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2-acetylamino-2-cyclohexylmethylmalonic acid diethyl ester (101426-47-5) → 2-amino-3-cyclohexylpropionic acid hydrochloride (99065-30-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; Heating;

DOI:10.1016/j.ejmech.2005.01.002

Reference yield:

Cyclohexylmethyl bromide (2550-36-9) → 2-amino-3-cyclohexylpropionic acid hydrochloride (99065-30-2)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / dimethyl sulfoxide / 12 h / 60 °C / Inert atmosphere

2: hydrogenchloride / water / 12 h / 100 °C

With hydrogenchloride; caesium carbonate; In water; dimethyl sulfoxide;

DOI:10.1016/j.ejmech.2018.04.034

Reference yield: 82.0%

ethanol (64-17-5) + 2-amino-3-cyclohexylpropionic acid hydrochloride (99065-30-2) → 2-amino-3-cyclohexylpropionic acid ethyl ester hydrochloride

Guidance literature:

With hydrogenchloride; at 0 ℃;

DOI:10.1016/j.ejmech.2005.01.002

upstream raw materials:

2-acetylamino-2-cyclohexylmethylmalonic acid diethyl ester

Cyclohexylmethyl bromide

Downstream raw materials:

2-(2-aminobenzoylamino)-3-cyclohexylpropionic acid ethyl ester

3-cyclohexyl-2-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}propionic acid ethyl ester

N-(Benzyloxycarbonyl)-2(S)-amino-3-cyclohexylpropionic acid

2-Bromo-3-cyclohexyl-propionyl chloride

Refernces

• 1、 Mandai, Hiroki,Hongo, Kohei,Fujiwara, Takuma,Fujii, Kazuki,Mitsudo, Koichi,Suga, Seiji. "Dynamic Kinetic Resolution of Azlactones by a Chiral N, N-Dimethyl-4-aminopyridine Derivative Containing a 1,1′-Binaphthyl Unit: Importance of Amide Groups". supporting information. p. 4811 - 4814. Retrieved 2018/08/24.