BOC-L-2,4-DIAMINOBUTYRIC ACID(FMOC)

Base Information

• Chemical Name: BOC-L-2,4-DIAMINOBUTYRIC ACID(FMOC)
• CAS No.: 117106-21-5
• Molecular Formula: C24H28N2O6
• Molecular Weight: 440.496
• Hs Code.: 29242990
• Mol file: 117106-21-5.mol

Synonyms:Boc-Dab(Fmoc)-OH;Butanoicacid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-,(S)-;

Chemical Property of BOC-L-2,4-DIAMINOBUTYRIC ACID(FMOC)

Chemical Property:

• Vapor Pressure: 6.47E-19mmHg at 25°C
• Melting Point: 79-80 °C
• Refractive Index: 1.575
• Boiling Point: 670.91 °C at 760 mmHg
• PKA: 3.88±0.10(Predicted)
• Flash Point: 359.554 °C
• PSA: 113.96000
• Density: 1.244 g/cm³
• LogP: 4.67490
• Storage Temp.: Store at RT.

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-alpha-Boc-Nγ-Fmoc-L-2,4-diaminobutyric acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-L-2,4-DIAMINOBUTYRIC ACID(FMOC)

There total 6 articles about BOC-L-2,4-DIAMINOBUTYRIC ACID(FMOC) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.5%

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) + (2S)-4-amino-2-[(tert-butoxycarbonyl)amino]butanoic acid (25691-37-6,80445-78-9) → Nα-t-Boc-Nγ-(9-fluorenylmethyloxycarbonyl)-(L)-2,4-diaminobutyric acid (117106-21-5,131570-57-5)

Guidance literature:

With sodium hydrogencarbonate; In 1,4-dioxane; water; at 20 ℃; for 2h;

DOI:10.1016/S0968-0896(98)00232-6

Reference yield: 50.0%

1,4-dioxane (123-91-1,28347-88-8,28347-91-3,39449-24-6,54841-74-6) + H-Dab(Fmoc)-OH + tert-butyldicarbonate (34619-03-9) + sodium carbonate (497-19-8) → Nα-t-Boc-Nγ-(9-fluorenylmethyloxycarbonyl)-(L)-2,4-diaminobutyric acid (117106-21-5,131570-57-5)

Guidance literature:

In water;

Reference yield: 50.0%

tert-butyldicarbonate (34619-03-9) + (S)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-aminobutanoic acid (117106-22-6) → Nα-t-Boc-Nγ-(9-fluorenylmethyloxycarbonyl)-(L)-2,4-diaminobutyric acid (117106-21-5,131570-57-5)

Guidance literature:

With sodium carbonate; In 1,4-dioxane; 1.) 0 deg C, 1 h; 2.) r.t., 22 h;

DOI:10.1016/S0040-4020(01)86742-9

upstream raw materials:

tert-butyldicarbonate

(S)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-aminobutanoic acid

(fluorenylmethoxy)carbonyl chloride

(2S)-4-amino-2-[(tert-butoxycarbonyl)amino]butanoic acid

Refernces

• 1、 -. "Cyclosporins". . . Retrieved 2008/06/13.
• 2、 -. "Peptides and medical use thereof". . . Retrieved 2008/06/13.