N-(5-Chloro-2-pyridinyl)-2-[(4-cyanobenzoyl)amino]-5-methoxybenzamide hydrochloride

Base Information

• Chemical Name: N-(5-Chloro-2-pyridinyl)-2-[(4-cyanobenzoyl)amino]-5-methoxybenzamide hydrochloride
• CAS No.: 936539-81-0
• Molecular Formula: C₂₁H₁₅ClN₄O₃*ClH
• Molecular Weight: 443.289
• Mol file: 936539-81-0.mol

Synonyms:N-(5-chloro-2-pyridinyl)-2-((4-cyanobenzoyl)amino)-5-methoxybenzamide hydrochloride

Chemical Property of N-(5-Chloro-2-pyridinyl)-2-[(4-cyanobenzoyl)amino]-5-methoxybenzamide hydrochloride

Chemical Property:

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(5-Chloro-2-pyridinyl)-2-[(4-cyanobenzoyl)amino]-5-methoxybenzamide hydrochloride

There total 3 articles about N-(5-Chloro-2-pyridinyl)-2-[(4-cyanobenzoyl)amino]-5-methoxybenzamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-amino-N-(5-chloro-pyridin-2-yl)-5-methoxy-benzamide (280773-17-3) + 4-cyanobenzoic Acid (619-65-8,333406-09-0) → N-(5-chloro-2-pyridinyl)-2-((4-cyanobenzoyl)amino)-5-methoxybenzamide hydrochloride (936539-81-0)

Guidance literature:

2-amino-N-(5-chloro-pyridin-2-yl)-5-methoxy-benzamide; 4-cyanobenzoic Acid; With dmap; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; In tetrahydrofuran; at 10 - 30 ℃; for 2h;

With hydrogenchloride; pH=2 - 3;

Reference yield: 85.17%

2-amino-N-(5-chloro-pyridin-2-yl)-5-methoxy-benzamide (280773-17-3) + 4-cyanobenzoyl chlorIde (6068-72-0) → N-(5-chloro-2-pyridinyl)-2-((4-cyanobenzoyl)amino)-5-methoxybenzamide hydrochloride (936539-81-0)

Guidance literature:

With dmap; In tetrahydrofuran; at 10 - 15 ℃; for 1h; Temperature; Concentration; Inert atmosphere;

Reference yield:

N-(5-chloro(2-pyridyl)){2-[(4-cyanophenyl)carbonylamino]-5-methoxyphenyl}carboxamide (330942-01-3) → N-(5-chloro-2-pyridinyl)-2-((4-cyanobenzoyl)amino)-5-methoxybenzamide hydrochloride (936539-81-0)

Guidance literature:

With hydrogenchloride; In methanol; ethyl acetate; at 0 ℃; Product distribution / selectivity;

upstream raw materials:

2-amino-N-(5-chloro-pyridin-2-yl)-5-methoxy-benzamide

4-cyanobenzoyl chlorIde

N-(5-chloro(2-pyridyl)){2-[(4-cyanophenyl)carbonylamino]-5-methoxyphenyl}carboxamide

4-cyanobenzoic Acid

Downstream raw materials:

betrixaban

Refernces

• 1、 -. "Preparation method of betrixaban". Paragraph 0012; 0028; 0029; 0065; 0067; 0068. . Retrieved 2016/10/10.
• 2、 -. "Unit dose formulations and methods of treating thrombosis with an oral factor Xa inhibitor". Page/Page column 25. . Retrieved 2008/12/06.