(2-(1,3-Dioxolan-2-yl)ethyl)triphenylphosphonium bromide

Base Information

• Chemical Name: (2-(1,3-Dioxolan-2-yl)ethyl)triphenylphosphonium bromide
• CAS No.: 86608-70-0
• Deprecated CAS: 888740-81-6
• Molecular Formula: C23H24 O2 P . Br
• Molecular Weight: 443.32
• Hs Code.: 2932999099
• European Community (EC) Number: 404-940-6,617-894-9
• DSSTox Substance ID: DTXSID70888675
• Mol file: 86608-70-0.mol

Synonyms:86608-70-0;2-(1,3-Dioxolan-2-yl)ethyltriphenylphosphonium bromide;(2-(1,3-Dioxolan-2-yl)ethyl)triphenylphosphonium bromide;Phosphonium, [2-(1,3-dioxolan-2-yl)ethyl]triphenyl-, bromide;2-(1,3-dioxolan-2-yl)ethyl-triphenylphosphanium;bromide;EC 404-940-6;(2-(1,3-Dioxolan-2-yl)ethyl)triphenyl-phosphonium bromide;Phosphonium, (2-(1,3-dioxolan-2-yl)ethyl)triphenyl-, bromide (1:1);Phosphonium, [2-(1,3-dioxolan-2-yl)ethyl]triphenyl-, bromide (1:1);[2-(1,3-dioxolan-2-yl)ethyl]triphenylphosphonium bromide;SCHEMBL1454426;DTXSID70888675;ZCJKBPSRKLHANV-UHFFFAOYSA-M;BCP21878;MFCD00075119;AKOS015833065;CS-W011599;D2056;FT-0608357;F17212;(2-(1,3-Dioxolan-2-yl)ethyl)triphenylphosphoniumbromide;2-(1,3-dioxolan-2-yl)ethyl-triphenylphosphonium bromide;[2-(1,3-dioxolan-2-yl)ethyl] triphenylphosphonium bromide;[2-(1,3-dioxolan-2-yl)ethyl]-triphenylphosphonium bromide;[2-(1,3-dioxolan-2-yl)-ethyl]-triphenylphosphonium bromide;2-(1,3-Dioxolan-2-yl)ethyltriphenylphosphonium bromide, 97%

Chemical Property of (2-(1,3-Dioxolan-2-yl)ethyl)triphenylphosphonium bromide

Chemical Property:

• Appearance/Colour: Pale yellow powder
• Melting Point: 144-146 ºC
• PSA: 32.05000
• LogP: 0.74750
• Solubility.: soluble in Methanol
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 442.06973
• Heavy Atom Count: 27
• Complexity: 357

Purity/Quality:

99% ^*data from raw suppliers

2-(1,3-Dioxolan-2-yl)ethyltriphenylphosphonium Bromide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-33-41-52/53
• Safety Statements: 22-26-39-61

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COC(O1)CC[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4.[Br-]
• Uses: suzuki reaction Reactant for:Wittig olefinationPreparationof ligands for histamine receptor binding with H3/H4 subtype selectivityPreparation of dual inhibitors of phosphodiesterase-4 and serotonin reuptake

Technology Process of (2-(1,3-Dioxolan-2-yl)ethyl)triphenylphosphonium bromide

There total 2 articles about (2-(1,3-Dioxolan-2-yl)ethyl)triphenylphosphonium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-bromo-2-(2-ethyl)dioxolane (18742-02-4) + triphenylphosphine (603-35-0) → 2-(1,3-dioxolan-2-yl)ethyl(triphenyl)phosphonium bromide (86608-70-0)

Guidance literature:

In acetonitrile; for 24h;

DOI:10.1021/jo980813u

Reference yield:

→ 2-(1,3-dioxolan-2-yl)ethyl(triphenyl)phosphonium bromide (86608-70-0)

Guidance literature:

Reference yield: 99.0%

C19H16O3 + 2-(1,3-dioxolan-2-yl)ethyl(triphenyl)phosphonium bromide (86608-70-0) → 2-(3-(1-(methoxymethoxy)-4-phenylnaphthalen-2-yl)allyl)-1,3-dioxolane

Guidance literature:

2-(1,3-dioxolan-2-yl)ethyl(triphenyl)phosphonium bromide; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 1h;

C₁₉H₁₆O₃; In tetrahydrofuran; hexane; at 0 ℃; for 14h;

DOI:10.1021/acs.orglett.9b04324

upstream raw materials:

2-bromo-2-(2-ethyl)dioxolane

triphenylphosphine

Downstream raw materials:

4-(2,5-dimethoxyphenyl)-3-butenal ethylene acetal

(Z)-4-(3-(1,3-dioxolan-2-yl)prop-1-enyl)-1-trityl-1H-imidazole

2-((E)-3-[1,3]Dioxolan-2-yl-propenyl)-benzoic acid methyl ester

4-((E)-3-[1,3]Dioxolan-2-yl-propenyl)-benzoic acid methyl ester

Refernces

• 1、 Dirat, Olivier,Kouklovsky, Cyrille,Langlois, Yves. "Oxazoline N-oxide-mediated [2 + 3] cycloadditions: Application to a total synthesis of the hypocholesterolemic agent 1233A". . p. 6634 - 6642. Retrieved 2007/10/03.
• 2、 -. "2-Hydroxy-4-(substituted) phenyl cycloalkanes and derivatives". . . Retrieved 2008/06/13.