Hydroxymethylphenylphosphinic acid

Base Information

• Chemical Name: Hydroxymethylphenylphosphinic acid
• CAS No.: 61451-78-3
• Molecular Formula: C7H9O3P
• Molecular Weight: 172.12
• Hs Code.: 2918199090
• Nikkaji Number: J1.961.472G
• Mol file: 61451-78-3.mol

Synonyms:HYDROXYMETHYLPHENYLPHOSPHINIC ACID;Phosphinic acid,P-(hydroxymethyl)-P-phenyl-;Hydroxymethyl phenylphosphinic acid;SCHEMBL6549541;SYBJZXZBVFWDAO-UHFFFAOYSA-N;(Hydroxymethyl)(phenyl)phosphinic acid;FT-0655639;J-521476

Chemical Property of Hydroxymethylphenylphosphinic acid

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.559
• Boiling Point: 445.008 °C at 760 mmHg
• Flash Point: 222.933 °C
• PSA: 80.67000
• Density: 1.348 g/cm³
• LogP: 1.02070
• Water Solubility.: 1704g/L(34.29 oC)
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 172.02893114
• Heavy Atom Count: 11
• Complexity: 163

Purity/Quality:

99% ^*data from raw suppliers

HYDROXYMETHYL PHENYLPHOSPHINIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)P(=O)(CO)O

Technology Process of Hydroxymethylphenylphosphinic acid

There total 7 articles about Hydroxymethylphenylphosphinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

benzyloxymethyl-phenyl-phosphinic acid ethyl ester (653584-99-7) → (hydroxymethyl)(phenyl)phosphinic acid (61451-78-3)

Guidance literature:

With hydrogenchloride; at 80 ℃; for 5h;

DOI:10.1055/s-2003-41045

Reference yield: 54.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + phenylphosphinic acid (1779-48-2) → (hydroxymethyl)(phenyl)phosphinic acid (61451-78-3)

Guidance literature:

With hydrogenchloride; In water; at 120 ℃; for 30h;

DOI:10.1007/s10870-011-0096-5

Reference yield:

iodobenzene (591-50-4) → (hydroxymethyl)(phenyl)phosphinic acid (61451-78-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / Et₃N / Pd(PPh₃)4 / toluene / 2.5 h / Heating

2: 96 percent / aq. HCl / 5 h / 80 °C

With hydrogenchloride; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene;

DOI:10.1055/s-2003-41045

upstream raw materials:

formaldehyd

ethyl Phenylphosphinate

benzyloxymethyl-phenyl-phosphinic acid ethyl ester

phenylphosphinic acid

Downstream raw materials:

phenyl(chloromethyl)phosphinic acid chloride

methyl hydroxymethanephenylphosphinate

Refernces

• 1、 Cristau, Henri-Jean,Pirat, Jean-Luc,Virieux, David,Monbrun, Jér?me,Ciptadi, Ciptadi,Bekro, Yves-Alain. "Synthesis, reactivity and stereochemistry of new phosphorus heterocycles with 5- or 6-membered rings". . p. 2472 - 2481. Retrieved 2007/10/03.
• 2、 -. "Process for the preparation of an oligomer flame-retarding additive and its use for endowing a linear polyester with self-extinguishing characteristics". . . Retrieved 2008/06/13.