2-AMINO-3-BENZOYL-4,5-DIMETHYLTHIOPHENE

Base Information

• Chemical Name: 2-AMINO-3-BENZOYL-4,5-DIMETHYLTHIOPHENE
• CAS No.: 42024-93-1
• Molecular Formula: C13H13NOS
• Molecular Weight: 231.318
• Hs Code.: 2934999090
• Mol file: 42024-93-1.mol

Synonyms:2-Amino-3-benzoyl-4,5-dimethylthiophene;

Chemical Property of 2-AMINO-3-BENZOYL-4,5-DIMETHYLTHIOPHENE

Chemical Property:

• Boiling Point: 401.2 °C at 760 mmHg
• Flash Point: 196.4 °C
• PSA: 71.33000
• Density: 1.205 g/cm³
• LogP: 3.75930
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%min ^*data from raw suppliers

(2-Amino-4,5-dimethylthien-3-yl)(phenyl)methanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-3-BENZOYL-4,5-DIMETHYLTHIOPHENE

There total 9 articles about 2-AMINO-3-BENZOYL-4,5-DIMETHYLTHIOPHENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-(3-benzoyl-4,5-dimethyl-thiophen-2-yl)acetamide (399043-17-5) → (2-amino-4,5-dimethylthiophen-3-yl)(phenyl)methanone (42024-93-1)

Guidance literature:

With potassium hydroxide; In methanol; for 0.75h; Heating;

DOI:10.1021/jm010081p

Reference yield: 89.0%

Benzoylacetonitrile (614-16-4) + butanone (78-93-3) → (2-amino-4,5-dimethylthiophen-3-yl)(phenyl)methanone (42024-93-1)

Guidance literature:

With morpholine; sulfur; In ethanol; at 70 ℃;

Reference yield: 50.0%

C13H12ClNO → (2-amino-4,5-dimethylthiophen-3-yl)(phenyl)methanone (42024-93-1) + 4,5-dimethyl-2-phenylthiophene-3-carbonitrile (65762-85-8)

Guidance literature:

C₁₃H₁₂ClNO; With sodium hydrogen sulfide; In ethanol; at -78 - 10 ℃;

With hydrogenchloride; water; In ethanol; dichloromethane;

DOI:10.1071/CH09004

upstream raw materials:

Benzoylacetonitrile

butanone

N-(3-benzoyl-4,5-dimethyl-thiophen-2-yl)acetamide

2,3-dimethylthiophene

Downstream raw materials:

(5,6-Dimethyl-2-methylsulfanyl-4-phenyl-4H-thieno[2,3-d]pyrimidin-3-yl)-acetic acid ethyl ester; hydriodide

3-benzyl-5,6-dimethyl-2-methylthio-4-phenyl-3,4-dihydrothieno<2,3-d>pyrimidine hydroiodide

(5,6-Dimethyl-4-phenyl-thieno[2,3-d]pyrimidin-2-ylamino)-acetic acid ethyl ester

ethyl 2-chloro-5,6-dimethyl-4-phenyl-3,4-dihydrothieno<2,3-d>pyrimidine-3-acetate

Refernces

• 1、 Aurelio, Luigi,Flynn, Bernard L.,Scammells, Peter J.. "Reaction pathways to 2-aminothiophenes and thiophene-3-carbonitriles". experimental part. p. 402 - 406. Retrieved 2009/12/01.
• 2、 -. "2-amino-3-aroyl-4,5 alkylthiophenes: agonist allosteric enhancers at human A1 adenosine receptors". . . Retrieved 2008/06/13.