1-AMINO-4-PHENYLCYCLOHEXANECARBOXYLIC ACID

Base Information

• Chemical Name: 1-AMINO-4-PHENYLCYCLOHEXANECARBOXYLIC ACID
• CAS No.: 117259-23-1
• Molecular Formula: C13H17NO2
• Molecular Weight: 219.28
• Mol file: 117259-23-1.mol

Synonyms:1-Amino-4-phenylcyclohexanecarboxylic acid;

Chemical Property of 1-AMINO-4-PHENYLCYCLOHEXANECARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.567
• Boiling Point: 387.71 °C at 760 mmHg
• Flash Point: 188.28 °C
• PSA: 63.32000
• Density: 1.161 g/cm³
• LogP: 2.82660

Purity/Quality:

99% ^*data from raw suppliers

1-Amino-4-phenylcyclohexanecarboxylicacid 97% ^*data from reagent suppliers

Safty Information:

• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-AMINO-4-PHENYLCYCLOHEXANECARBOXYLIC ACID

There total 5 articles about 1-AMINO-4-PHENYLCYCLOHEXANECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

hydantoin A → 1-amino-4-phenylcyclohexane-1-carboxylic acid (117259-23-1)

Guidance literature:

In sodium hydroxide;

Reference yield:

2,4-dioxo-8-phenyl-1,3-diaza-spiro[4.5]decane-1,3-dicarboxylic acid di-tert-butyl ester (868140-31-2) → 1-amino-4-phenylcyclohexane-1-carboxylic acid (117259-23-1)

Guidance literature:

With sodium hydroxide; In 1,2-dimethoxyethane; at 20 ℃;

DOI:10.1016/j.bmcl.2005.08.012

Reference yield:

1-phenyl-4-cyclohexanone (4894-75-1) → 1-amino-4-phenylcyclohexane-1-carboxylic acid (117259-23-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / ethanol; H₂O / 90 °C

2: 91 percent / Et₃N; DMAP / tetrahydrofuran / 20 °C

3: aq. NaOH / 1,2-dimethoxy-ethane / 20 °C

With dmap; sodium hydroxide; triethylamine; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; 1: Bucherer-Bergs reaction;

DOI:10.1016/j.bmcl.2005.08.012

upstream raw materials:

2,4-dioxo-8-phenyl-1,3-diaza-spiro[4.5]decane-1,3-dicarboxylic acid di-tert-butyl ester

1-phenyl-4-cyclohexanone

8-phenyl-1,3-diazaspiro[4.5]decan-2,4-dione

Downstream raw materials:

Fmoc-Apc-OH

Refernces

• 1、 -. "Selective cyclic peptides with melanocortin-4 receptor (MC4-R) agonist activity". . . Retrieved 2008/06/13.