(S)-2-CHLORO-1-(3,4-DICHLOROPHENYL)ETHANOL

Base Information

• Chemical Name: (S)-2-CHLORO-1-(3,4-DICHLOROPHENYL)ETHANOL
• CAS No.: 256474-24-5
• Molecular Formula: C8H7 Cl3 O
• Molecular Weight: 225.502
• Hs Code.: 2906299090
• Mol file: 256474-24-5.mol

Synonyms:(S)-2-CHLORO-1-(3,4-DICHLOROPHENYL)ETHANOL

Chemical Property of (S)-2-CHLORO-1-(3,4-DICHLOROPHENYL)ETHANOL

Chemical Property:

• PSA: 20.23000
• LogP: 3.26560

Purity/Quality:

99.5% ^*data from raw suppliers

(1S)-2-chloro-1-(3,4-dichlorophenyl)ethan-1-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-2-CHLORO-1-(3,4-DICHLOROPHENYL)ETHANOL

There total 4 articles about (S)-2-CHLORO-1-(3,4-DICHLOROPHENYL)ETHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2,3',4'-trichloroacetophenone (42981-08-8) → (S)-2-Chloro-1-(3,4-dichlorophenyl)ethan-1-ol (256474-24-5)

Guidance literature:

With D-glucose; Geotrichum candidum; malt; XAD-1180; peptone; at 28 ℃; for 48h;

DOI:10.1016/S0957-4166(99)00402-4

Reference yield:

rac-octan-2-ol (4128-31-8,113301-48-7,4128-32-9) + 2,3',4'-trichloroacetophenone (42981-08-8) → (S)-2-Octanol (6169-06-8,113301-48-7,4128-32-9) + (S)-2-Chloro-1-(3,4-dichlorophenyl)ethan-1-ol (256474-24-5)

Guidance literature:

With Tris-HCl buffer; at 30 ℃; for 24h; pH=7.5; enantioselective reaction; Enzymatic reaction;

DOI:10.1021/jo802350f

Reference yield:

2,3',4'-trichloroacetophenone (42981-08-8) → (S)-2-Chloro-1-(3,4-dichlorophenyl)ethan-1-ol (256474-24-5) + (R)-2-chloro-1-(3,4-dichlorophenyl)ethan-1-ol

Guidance literature:

With D-glucose; D-glucose dehydrogenase; NADPH; alcohol dehydrogenase YMR₂₂₆c; In dimethyl sulfoxide; at 20 ℃; pH=6.5; Title compound not separated from byproducts.;

DOI:10.1016/j.tetasy.2007.08.008

upstream raw materials:

2,3',4'-trichloroacetophenone

rac-octan-2-ol

Downstream raw materials:

(S)-(+)-(3,4-Dichlorophenyl)oxirane

Refernces

• 1、 Ibn Majdoub Hassani, Fatima Zohra,Amzazi, Saaid,Kreit, Joseph,Lavandera, Iván. "Deep Eutectic Solvents as Media in Alcohol Dehydrogenase-Catalyzed Reductions of Halogenated Ketones". . p. 832 - 836. Retrieved 2019/12/24.
• 2、 Li, Aipeng,Ye, Lidan,Yang, Xiaohong,Wang, Bei,Yang, Chengcheng,Gu, Jiali,Yu, Hongwei. "Reconstruction of the Catalytic Pocket and Enzyme–Substrate Interactions To Enhance the Catalytic Efficiency of a Short-Chain Dehydrogenase/Reductase". . p. 3229 - 3233. Retrieved 2016/10/24.