4-CHLORO-5,6-DIMETHYLTHIENO[2,3-D]PYRIMIDINE

Base Information

• Chemical Name: 4-CHLORO-5,6-DIMETHYLTHIENO[2,3-D]PYRIMIDINE
• CAS No.: 108831-68-1
• Molecular Formula: C8H7ClN2S
• Molecular Weight: 198.676
• Hs Code.: 29335990
• Mol file: 108831-68-1.mol

Synonyms:NSC 153302;

Chemical Property of 4-CHLORO-5,6-DIMETHYLTHIENO[2,3-D]PYRIMIDINE

Chemical Property:

• Vapor Pressure: 0.000514mmHg at 25°C
• Melting Point: 112 °C
• Refractive Index: 1.66
• Boiling Point: 322.83 °C at 760 mmHg
• Flash Point: 149.043 °C
• PSA: 54.02000
• Density: 1.38 g/cm³
• LogP: 2.96150
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Chloro-5,6-dimethylthieno[2,3-d]pyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 26-36-22-20/21/22
• Safety Statements: 26-36/37-3/7

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Employed as a intermediate for pharmaceutical.

Technology Process of 4-CHLORO-5,6-DIMETHYLTHIENO[2,3-D]PYRIMIDINE

There total 7 articles about 4-CHLORO-5,6-DIMETHYLTHIENO[2,3-D]PYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

5,6-dimethyl-1H-thieno[2,3-d]pyrimidin-4-one (18593-44-7) → 4-chloro-5,6-dimethyl-thieno[2,3-d]pyrimidine (108831-68-1)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; at 110 ℃; for 3h;

Reference yield: 91.0%

5,6-dimethylthieno<2,3-d>pyrimidin-4(3H)-one (18593-44-7) → 4-chloro-5,6-dimethyl-thieno[2,3-d]pyrimidine (108831-68-1)

Guidance literature:

With trichlorophosphate; Reflux;

DOI:10.1016/j.ejmech.2016.07.035

Reference yield: 76.0%

5,6-dimethyl-3H-thieno[2,3-d]pyrimidin-4-one (18593-44-7) → 4-chloro-5,6-dimethyl-thieno[2,3-d]pyrimidine (108831-68-1)

Guidance literature:

With trichlorophosphate; for 2h; Reflux;

upstream raw materials:

5,6-dimethyl-1H-thieno[2,3-d]pyrimidin-4-one

5,6-dimethylthieno<2,3-d>pyrimidin-4(3H)-one

2-amino-4,5-dimethyl-3-thiophenecarboxylic acid ethyl ester

5,6-dimethyl-3H-thieno[2,3-d]pyrimidin-4-one

Downstream raw materials:

C₁₉H₂₇N₃O₃S

tert-butyl N-{4-[(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)oxy]cyclohexyl}-N-methylcarbamate

4-[(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)oxy]-N-methylcyclohexan-1-amine

C₁₄H₁₃N₃S

Refernces

• 1、 Oh, Changmok,Kim, Hyuntae,Kang, Jong Soon,Yun, Jieun,Sim, Jaejun,Kim, Hwan-Mook,Han, Gyoonhee. "Synthetic strategy for increasing solubility of potential FLT3 inhibitor thieno[2,3-d]pyrimidine derivatives through structural modifications at the C2and C6positions". . p. 496 - 500. Retrieved 2017.
• 2、 Balanda, A. O.,Bdzhola, V. G.,Kotey, I. M.,Pletnova, L. V.,Protopopov, M. V.,Prykhod’ko, A. O.,Starosyla, S. A.,Yarmoluk, S. M.. "Identification of 4-methoxythieno[2,3-d]pyrimidines as FGFR1 inhibitors". . p. 152 - 162. Retrieved 2020/06/02.