DIMETHYL 3-METHYLGLUTARATE

Base Information

• Chemical Name: DIMETHYL 3-METHYLGLUTARATE
• CAS No.: 19013-37-7
• Molecular Formula: C8H14O4
• Molecular Weight: 174.197
• Hs Code.: 2917190090
• Mol file: 19013-37-7.mol

Synonyms:Glutaricacid, 3-methyl-, dimethyl ester (8CI);Pentanedioic acid, 3-methyl-, dimethylester (9CI);Dimethyl 3-methylglutarate;Dimethyl 3-methylpentanedioate;Methyl3-methylglutarate;

Chemical Property of DIMETHYL 3-METHYLGLUTARATE

Chemical Property:

• Vapor Pressure: 0.11mmHg at 25°C
• Refractive Index: n20/D 1.425(lit.)
• Boiling Point: 221 °C at 760 mmHg
• Flash Point: 90.8 °C
• PSA: 52.60000
• Density: 1.037 g/cm³
• LogP: 0.74870

Purity/Quality:

98%,99%, ^*data from raw suppliers

Dimethyl 3-methylglutarate 99% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Dimethyl 3-methylglutarate may be used in the synthesis of (R)- and (S)-4-amino-3-methylbutanoic acids, via initial enantioselective hydrolysis with pig liver esterase. It may be used in the preparation of optically active form of verrucarinic acid derivative. It may be used as building block for chemoenzymatic asymmetric synthesis.

Technology Process of DIMETHYL 3-METHYLGLUTARATE

There total 15 articles about DIMETHYL 3-METHYLGLUTARATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methanol (67-56-1) + 3-methylglutaric anhydride (4166-53-4) → dimethyl 3-methylglutarate (19013-37-7)

Guidance literature:

With hydrogenchloride; sulfuric acid; In water; at 70 ℃; for 12h; Inert atmosphere;

DOI:10.1021/ml500161v

Reference yield: 93.0%

2-methylpropan-1,1,3-tricarboxylic acid trimethyl ester (65844-74-8) → dimethyl 3-methylglutarate (19013-37-7)

Guidance literature:

With sodium chloride; In water; dimethyl sulfoxide; for 4.5h; Heating;

DOI:10.1016/S0040-4020(01)85099-7

Reference yield: 91.0%

3-methyl-2-pentene-1,5-diacid dimethyl (52313-87-8) → dimethyl 3-methylglutarate (19013-37-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; at 65 ℃; under 3040 Torr;

DOI:10.1016/S0040-4020(01)85927-5

upstream raw materials:

methanol

3-methyl glutaric acid

3-methylpentanedioyl dichloride

dimethyl (2E)-pent-2-enedioate

Downstream raw materials:

3-methylpentane-1,5-diol

(R)-3-methylpentanedioic acid monomethyl ester

(S)-5-methoxy-3-methyl-5-oxopentanoic acid

2-methyl-1.3-propanediol

Refernces

• 1、 Kohl,Irschik,Reichenbach,Hofle. "Antibiotics from gliding bacteria, XVII. - Myxopyronin A and B - Two novel antibiotics from Myxococcus fulvus strain Mx f50". . p. 1656 - 1667. Retrieved 1983.
• 2、 Phillips, Andrew W.,Anketell, Matthew J.,Balan, Tudor,Lam, Nelson Y. S.,Williams, Simon,Paterson, Ian. "Toward the total synthesis of patellazole B: Synthesis of an advanced C1-C25 fragment corresponding to the macrocyclic skeleton". supporting information. p. 6908 - 6913. Retrieved 2018/10/02.
• 3、 -. "Method for synthesizing muscone by utilizing beta-monomethyl methylglutarate". Paragraph 0021; 0022. . Retrieved 2017/12/05.