Benzyldiphenylphosphine

Base Information

• Chemical Name: Benzyldiphenylphosphine
• CAS No.: 7650-91-1
• Molecular Formula: C19H17P
• Molecular Weight: 276.318
• Hs Code.: 29310099
• Mol file: 7650-91-1.mol

Synonyms:phosphine, diphenyl(phenylmethyl)-;Phosphine, benzyldiphenyl-;Benzyl(diphenyl)phosphine;Diphenyl(phenylmethyl)phosphine;

Chemical Property of Benzyldiphenylphosphine

Chemical Property:

• Appearance/Colour: White to off-white powder
• Vapor Pressure: 3.12E-06mmHg at 25°C
• Melting Point: 77-83 °C
• Boiling Point: 399.6 °C at 760 mmHg
• Flash Point: 206.2 °C
• PSA: 13.59000
• LogP: 4.31950
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive.: Air Sensitive
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

99% ^*data from raw suppliers

Benzyldiphenylphosphine, 99% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: suzuki reaction Employed as a catalyst for Suzuki cross-coupling and antiarthritic agent (inhibitor of cathepsin B). It is also used as catalyst in pharmaceutical research.

Technology Process of Benzyldiphenylphosphine

There total 38 articles about Benzyldiphenylphosphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

benzyl bromide (100-39-0) + diphenylphosphane (829-85-6) → benzyldiphenylphosphane (7650-91-1)

Guidance literature:

With [Cu(9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene)(NCMe)][PF₆]*2(CH₂Cl₂); sodium trimethylsilanolate; In tetrahydrofuran; dichloromethane; at 20 ℃; for 0.25h; Inert atmosphere;

DOI:10.1021/ic100816u

Reference yield: 93.0%

benzyl chloride (100-44-7) + diphenylphosphane (829-85-6) → benzyldiphenylphosphane (7650-91-1)

Guidance literature:

With [(1,1,1-tris(diphenylphosphinomethyl)ethane)Cu(NCMe)][PF₆]; sodium trimethylsilanolate; In tetrahydrofuran; at 20 ℃; for 0.25h; Inert atmosphere;

DOI:10.1021/ic100816u

Reference yield: 78.0%

diphenylphosphonium chloride + toluene (108-88-3,15644-74-3,16713-13-6) → benzyldiphenylphosphane (7650-91-1)

Guidance literature:

toluene; With n-butyllithium; In hexane; at 0 - 20 ℃; for 24h; Inert atmosphere;

diphenylphosphonium chloride; In hexane; at 20 ℃; for 3h; Inert atmosphere;

upstream raw materials:

benzyltriphenylphosphonium chloride

Methylenetriphenylphosphorane

benzyltrimethylammonium iodide

sodium diphenylphosphide

Downstream raw materials:

diphenyldibenzylphosphonium chloride

2,2,3-Triphenyl-1H-2λ⁵-benzo[e][1,2]azaphosphinin-4-one

NiCl₂(diphenylbenzylphosphine)2

NiBr₂(diphenylbenzylphosphine)2

Refernces

• 1、 Cui, Penglei,Li, Sida,Wang, Xianjin,Li, Ming,Wang, Chun,Wu, Lipeng. "Visible-Light-Promoted Unsymmetrical Phosphine Synthesis from Benzylamines". supporting information. p. 1566 - 1570. Retrieved 2022/03/01.
• 2、 Arockiam, Percia Beatrice,Lennert, Ulrich,Graf, Christina,Rothfelder, Robin,Scott, Daniel J.,Fischer, Tillmann G.,Zeitler, Kirsten,Wolf, Robert. "Versatile Visible-Light-Driven Synthesis of Asymmetrical Phosphines and Phosphonium Salts". supporting information. p. 16374 - 16382. Retrieved 2020/11/03.