6-(Fmoc-amino)-1-hexanol

Base Information

• Chemical Name: 6-(Fmoc-amino)-1-hexanol
• CAS No.: 127903-20-2
• Molecular Formula: C21H25NO3
• Molecular Weight: 339.434
• Hs Code.: 2921490090
• DSSTox Substance ID: DTXSID30371396
• Nikkaji Number: J1.307.811D
• Wikidata: Q82158715
• Mol file: 127903-20-2.mol

Synonyms:6-(Fmoc-amino)-1-hexanol;127903-20-2;9H-fluoren-9-ylmethyl N-(6-hydroxyhexyl)carbamate;(9H-Fluoren-9-yl)methyl (6-hydroxyhexyl)carbamate;(9H-FLUOREN-9-YL)METHYL N-(6-HYDROXYHEXYL)CARBAMATE;6-Fmoc-Acp-ol;Fmoc-Acp(6)-ol;Maybridge1_008870;SCHEMBL887559;HMS566L04;DTXSID30371396;Carbamic acid, (6-hydroxyhexyl)-, 9H-fluoren-9-ylmethyl ester;Carbamic acid, N-(6-hydroxyhexyl)-, 9H-fluoren-9-ylmethyl ester;MFCD00380196;AKOS015910691;AS-9476;CCG-255262;6-(Fmoc-amino)-1-hexanol, >=98.0%;CS-0149653;FT-0621667;9H-Fluoren-9-ylmethyl 6-hydroxyhexylcarbamate;W18763;(9H-fluoren-9-yl)methyl 6-hydroxyhexylcarbamate;EN300-5151267;J-005554;N-(Fluoren-9-ylmethoxycarbonyl)-6-aminohexan-1-ol;6-Hydroxyhexylcarbamic acid 9H-fluorene-9-ylmethyl ester;Carbamic acid,N-(6-hydroxyhexyl)-,9H-fluoren-9-ylmethylester

Chemical Property of 6-(Fmoc-amino)-1-hexanol

Chemical Property:

• Vapor Pressure: 1.86E-12mmHg at 25°C
• Melting Point: 119 °C
• Refractive Index: 1.578
• Boiling Point: 539.2 °C at 760 mmHg
• Flash Point: 279.9 °C
• PSA: 58.56000
• Density: 1.151 g/cm³
• LogP: 4.46870
• Storage Temp.: 2-8°C
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 9
• Exact Mass: 339.18344366
• Heavy Atom Count: 25
• Complexity: 392

Purity/Quality:

98%Min ^*data from raw suppliers

6-(Fmoc-amino)-1-hexanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Safety Statements: S24/25:Avoid contact with skin and eyes.

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NCCCCCCO
• Uses: Reagent for the introduction of a spacer arm

Technology Process of 6-(Fmoc-amino)-1-hexanol

There total 11 articles about 6-(Fmoc-amino)-1-hexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

6-amino-1-hexanol (4048-33-3) + N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) → 9H-fluoren-9-ylmethyl N-(6-hydroxyhexyl)carbamate (127903-20-2)

Guidance literature:

With pyridine; In methanol; at 23 ℃; for 16h;

DOI:10.1021/ja012026b

Reference yield: 98.0%

6-amino-1-hexanol (4048-33-3) + (fluorenylmethoxy)carbonyl chloride (28920-43-6) → 9H-fluoren-9-ylmethyl N-(6-hydroxyhexyl)carbamate (127903-20-2)

Guidance literature:

With sodium carbonate; In 1,4-dioxane; at 0 - 25 ℃; for 12h;

Reference yield: 77.0%

(9H-fluoren-9-yl)methyl (6-((4-methoxybenzyl)oxy)hexyl)carbamate (1308344-03-7) → 9H-fluoren-9-ylmethyl N-(6-hydroxyhexyl)carbamate (127903-20-2)

Guidance literature:

With sodium hydrogen sulfate; eosin; dihydrogen peroxide; In water; acetonitrile; for 48h; Irradiation;

DOI:10.1002/adsc.201400936

upstream raw materials:

6-amino-1-hexanol

(fluorenylmethoxy)carbonyl chloride

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

1,6-hexanediol

Downstream raw materials:

VO(OCH₂CH(CH₃)2)2(OC₆H₄NH₂)

2-benzyl-3-[{1-[(9H-fluoren-9-ylmethoxy)carbonyl]-2-azepanyl}(hydroxy)phosphoryl]propanoic acid

2-benzyl-3-oxo-(2-oxo-2-phenylethoxy)propyl{1-[(9H-fluoren-9-ylmethoxy)carbonyl]-2-azepanyl}phosphinic acid

Refernces

• 1、 Matsumori, Nobuaki,Yamaji, Nahoko,Matsuoka, Shigeru,Oishi, Tohru,Murata, Michio. "Amphotericin B covalent dimers forming sterol-dependent ion-permeable membrane channels". . p. 4180 - 4181. Retrieved 2002.
• 2、 Le Roux, Antoine,Blaise, émilie,Boudreault, Pierre-Luc,Comeau, Christian,Doucet, Annie,Giarrusso, Marilena,Collin, Marie-Pierre,Neubauer, Thomas,K?lling, Florian,G?ller, Andreas H.,Seep, Lea,Tshitenge, Dieudonné T.,Wittwer, Matthias,Kullmann, Maximilian,Hillisch, Alexander,Mittendorf, Joachim,Marsault, Eric. "Structure-Permeability Relationship of Semipeptidic Macrocycles - Understanding and Optimizing Passive Permeability and Efflux Ratio". supporting information. p. 6774 - 6783. Retrieved 2020/07/28.
• 3、 Liu, Zheng,Zhang, Yi,Cai, Zheren,Sun, Hao,Cheng, Xu. "Photoredox removal of p-methoxybenzyl ether protecting group with hydrogen peroxide as terminal oxidant". supporting information. p. 589 - 593. Retrieved 2015/03/05.