FMOC-ILE-OL

Base Information

• Chemical Name: FMOC-ILE-OL
• CAS No.: 133565-46-5
• Molecular Formula: C₂₁H₂₅NO₃
• Molecular Weight: 339.434
• Mol file: 133565-46-5.mol

Synonyms:Carbamic acid, [1-(hydroxymethyl)-2-methylbutyl]-, 9H-fluoren-9-ylmethylester, [S-(R*,R*)]-;

Chemical Property of FMOC-ILE-OL

Chemical Property:

• Appearance/Colour: White Powder
• Refractive Index: 1.576
• Boiling Point: 525.204 °C at 760 mmHg
• Flash Point: 271.434 °C
• PSA: 58.56000
• Density: 1.149 g/cm³
• LogP: 4.32300
• Storage Temp.: Store at 0°C

Purity/Quality:

98.5% ^*data from raw suppliers

Fmoc-L-isoleucinol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of FMOC-ILE-OL

There total 4 articles about FMOC-ILE-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(S)-4-((S)-sec-Butyl)-2,5-dioxo-oxazolidine-3-carboxylic acid 9H-fluoren-9-ylmethyl ester (129288-41-1) → Fmoc-Ile-ol (133565-46-5)

Guidance literature:

With sodium tetrahydroborate; In 1,2-dimethoxyethane; water; for 0.166667h; Ambient temperature;

DOI:10.1016/S0040-4039(00)75840-0

Reference yield: 88.0%

Fmoc-Ile-N3 (329308-99-8) → Fmoc-Ile-ol (133565-46-5)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; water; cooling;

Reference yield: 78.0%

Fmoc-Ile-OH (71989-23-6,251316-98-0) → Fmoc-Ile-ol (133565-46-5)

Guidance literature:

Fmoc-Ile-OH; With 1,3,5-trichloro-2,4,6-triazine; potassium carbonate; triphenylphosphine; In neat (no solvent); for 0.166667h; Green chemistry;

With sodium tetrahydroborate; In neat (no solvent); for 0.0833333h; Green chemistry;

DOI:10.1039/c4ra08643k

upstream raw materials:

(S)-4-((S)-sec-Butyl)-2,5-dioxo-oxazolidine-3-carboxylic acid 9H-fluoren-9-ylmethyl ester

Fmoc-Ile-OCO₂i-Bu

Fmoc-Ile-N₃

Fmoc-Ile-OH

Refernces

• 1、 Jaita, Subin,Kaewkum, Pantitra,Duangkamol, Chuthamat,Phakhodee, Wong,Pattarawarapan, Mookda. "Solvent-free reduction of carboxylic acids to alcohols with NaBH4 promoted by 2,4,6-trichloro-1,3,5-triazine and PPh3 in the presence of K2CO3". . p. 46947 - 46950. Retrieved 2014/12/10.
• 2、 Sureshbabu, Vommina V.,Naik, Shankar A.,Hemantha,Narendra,Das, Ushati,Guru Row, Tayur N.. "N-urethane-protected amino alkyl isothiocyanates: Synthesis, isolation, characterization, and application to the synthesis of thioureidopeptides". supporting information; experimental part. p. 5260 - 5266. Retrieved 2009/12/06.