2-Fluoro-6-methoxybenzaldehyde

Base Information

• Chemical Name: 2-Fluoro-6-methoxybenzaldehyde
• CAS No.: 146137-74-8
• Molecular Formula: C8H7FO2
• Molecular Weight: 154.141
• Hs Code.: 29130000
• European Community (EC) Number: 627-181-4
• DSSTox Substance ID: DTXSID00372012
• Nikkaji Number: J2.390.681C
• Wikidata: Q72473943
• Mol file: 146137-74-8.mol

Synonyms:2-Fluoro-6-methoxybenzaldehyde;146137-74-8;2-Fluoro-6-mehoxybenzaldehyde;2-methoxy-6-fluorobenzaldehyde;Benzaldehyde, 2-fluoro-6-methoxy-;MFCD01090998;2-Fluoro-6-methoxybenzaldehyde, 98%;6-Fluoro-o-anisaldehyde;2-Fluoro-6-methoxy-benzaldehyde;SCHEMBL305745;2-fluoro-6-methoxylbenzaldehyde;2-Fluoro-6-Methoxy Benzaldehyde;DTXSID00372012;UIOAYOIJMYMOEU-UHFFFAOYSA-N;2-fluoranyl-6-methoxy-benzaldehyde;CS-M0642;CL9084;AKOS005063829;PS-8888;AC-24747;SY038163;AM20060042;F1175;FT-0643390;EN300-137050;A808456;J-509488;Z1203161972

Chemical Property of 2-Fluoro-6-methoxybenzaldehyde

Chemical Property:

• Vapor Pressure: 0.011mmHg at 25°C
• Melting Point: 59-63 °C(lit.)
• Refractive Index: n20/D 1.339
• Boiling Point: 218.5 °C at 760 mmHg
• Flash Point: 83.7 °C
• PSA: 26.30000
• Density: 1.192 g/cm³
• LogP: 1.64680
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Sensitive.: Air Sensitive
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 154.04300762
• Heavy Atom Count: 11
• Complexity: 138

Purity/Quality:

99% ^*data from raw suppliers

2-Fluoro-6-methoxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C(=CC=C1)F)C=O

Technology Process of 2-Fluoro-6-methoxybenzaldehyde

There total 8 articles about 2-Fluoro-6-methoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-fluoro-3-methoxybenzene (456-49-5) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-fluoro-6-methoxybenzaldehyde (146137-74-8)

Guidance literature:

1-fluoro-3-methoxybenzene; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; for 1h;

With hydrogenchloride; water; In tetrahydrofuran; hexane;

Reference yield: 95.0%

2-fluoro-6-methoxybenzonitrile (94088-46-7) → 2-fluoro-6-methoxybenzaldehyde (146137-74-8)

Guidance literature:

With diisobutylaluminium hydride; In hexane; toluene; at -78 - 20 ℃;

DOI:10.1021/jo991958j

Reference yield: 58.0%

2-fluoro-6-methoxybenzyl alcohol (253668-46-1) → 2-fluoro-6-methoxybenzaldehyde (146137-74-8)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 20 ℃; for 2h;

upstream raw materials:

N-Formylpiperidine

1-fluoro-3-methoxybenzene

N,N-dimethyl-formamide

2-fluoro-6-methoxybenzonitrile

Downstream raw materials:

2-(2-fluoro-6-methoxyphenyl)acetonitrile

1-ethyl-3-(2-fluoro-6-hydroxyphenyl)-7-((5-(methyl(1-methylpiperidin-4-yl)amino)pyridin-2-yl)amino)-1,6-naphthyridin-2(1H)-one

7-chloro-1-ethyl-3-(2-fluoro-6-methoxyphenyl)-1,6-naphthyridin-2(1H)-imine

7-chloro-1-ethyl-3-(2-fluoro-6-methoxyphenyl)-1,6-naphthyridin-2(1H)-one

Refernces

• 1、 -. "List fluoro Radicamine compounds and their use and preparation method". Paragraph 0086-0088. . Retrieved 2017/12/02.
• 2、 Bieszczad, Bartosz,Barbasiewicz, Micha?. "The Key Role of the Nonchelating Conformation of the Benzylidene Ligand on the Formation and Initiation of Hoveyda-Grubbs Metathesis Catalysts". supporting information. p. 10322 - 10325. Retrieved 2015/07/07.