1-(4-chlorobenzyl)azepane

Base Information

• Chemical Name: 1-(4-chlorobenzyl)azepane
• CAS No.: 112376-91-7
• Molecular Formula: C₁₃H₁₈ClN
• Molecular Weight: 223.746
• Mol file: 112376-91-7.mol

Synonyms:1-(4-chlorobenzyl)azepane

Chemical Property of 1-(4-chlorobenzyl)azepane

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-chlorobenzyl)azepane

There total 3 articles about 1-(4-chlorobenzyl)azepane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-chlorobenzaldehyde (104-88-1) + 6-aminohexanoic acid (60-32-2,93208-38-9) → 1-(4-chlorobenzyl)azepane (112376-91-7)

Guidance literature:

With [(1,3-bis(2,4,6-trimethylphenyl) imidazol-2-ylidene)Fe(CO)₄]; phenylsilane; In toluene; at 100 ℃; for 20h; Schlenk technique; Inert atmosphere; Irradiation;

DOI:10.1002/cssc.201900519

Reference yield: 51.0%

hexamethylene imine (111-49-9) + 4-chlorobenzaldehyde (104-88-1) → 1-(4-chlorobenzyl)azepane (112376-91-7)

Guidance literature:

With 3,5-dinitrobenzoic acid; In m-xylene; for 26h; diastereoselective reaction; Reflux;

DOI:10.1021/acs.orglett.5b01744

Reference yield:

hexamethylene imine (111-49-9) + 1-Chloro-4-(chloromethyl)benzene (104-83-6) → 1-(4-chlorobenzyl)azepane (112376-91-7)

Guidance literature:

With benzene;

upstream raw materials:

hexamethylene imine

1-Chloro-4-(chloromethyl)benzene

4-chlorobenzaldehyde

6-aminohexanoic acid

Refernces

• 1、 Mandal, Sumana,Mahato, Sujit,Jana, Chandan K.. "Direct β-C(sp3)-H Functionalization of Aliphatic Amines to α,β-Unsaturated Imines, Aldehydes, and Chromenes". supporting information. p. 3762 - 3765. Retrieved 2015/08/18.