Sulconazle Nitrate

Base Information

• Chemical Name: Sulconazle Nitrate
• CAS No.: 82382-23-8
• Molecular Formula: C₁₈H₁₅Cl₃N₂S*HNO₃
• Molecular Weight: 460.768
• Hs Code.: 2933290090
• Mol file: 82382-23-8.mol

Synonyms:1-{2-[(4-Chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole nitrate (1:1);

Chemical Property of Sulconazle Nitrate

Chemical Property:

• Boiling Point: 558.2 °C at 760 mmHg
• Flash Point: 291.4 °C
• PSA: 109.17000
• LogP: 6.69350
• Storage Temp.: Refrigerator
• Solubility.: Acetonitrile (Slightly, Heated), Methanol (Slightly), Water (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

Sulconazole nitrate United States Pharmacopeia (USP) Reference Standard ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Sulconazole nitrate is an imidazole antifungal agent closely related to econazole. It is effective in the topical treatment of a broad spectrum of superficial fungal infections.
• Uses: Antifungal.
• Clinical Use: 1-[2,4-Dichloro-β-[p-chlorobenzyl)thio]phenethyl]imidazolemononitrate (Exelderm) is the white crystalline nitricacid salt of sulconazole. It is sparingly soluble in water butsoluble in ethanol. The salt is used in a solution and a cream in 1% concentration for the treatment of local tinea infections,such as jock itch, athlete’s foot, and ringworm.

Technology Process of Sulconazle Nitrate

There total 2 articles about Sulconazle Nitrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-chloro-1-(2,4-dichlorophenyl)-2-(1H-imidazole-1-yl)ethane (46503-49-5) + (4-chlorophenyl)methanethiol (6258-66-8) → sulconazole nitrate (61318-91-0,82382-23-8)

Guidance literature:

With sodium chloride; In tetrahydrofuran; mineral oil;

Reference yield:

→ sulconazole nitrate (61318-91-0,82382-23-8)

Guidance literature:

upstream raw materials:

1-chloro-1-(2,4-dichlorophenyl)-2-(1H-imidazole-1-yl)ethane

(4-chlorophenyl)methanethiol

Refernces

• 1、 -. "1-[β(R-thio)phenethyl]imidazoles and derivatives thereof". . . Retrieved 2008/06/13.