4-Chlorophenylhydrazine

Base Information

• Chemical Name: 4-Chlorophenylhydrazine
• CAS No.: 1073-69-4
• Molecular Formula: C6H7ClN2
• Molecular Weight: 142.588
• Hs Code.: 2928000090
• European Community (EC) Number: 214-029-3
• DSSTox Substance ID: DTXSID50147999
• Nikkaji Number: J141.361I
• Wikidata: Q27124142
• Metabolomics Workbench ID: 58695
• Mol file: 1073-69-4.mol

Synonyms:4-chlorophenylhydrazine;4-chlorophenylhydrazine hydrochloride;4-chlorophenylhydrazine monohydrochloride;4-chlorophenylhydrazine oxalate (1:1);4-chlorophenylhydrazine sulfate;4-chlorophenylhydrazine sulfate (2:1)

Chemical Property of 4-Chlorophenylhydrazine

Chemical Property:

• Appearance/Colour: white or off-white power
• Vapor Pressure: 0.00926mmHg at 25°C
• Melting Point: 85 °C
• Boiling Point: 265.3 °C at 760 mmHg
• PKA: 5.00±0.20(Predicted)
• Flash Point: 114.2 °C
• PSA: 38.05000
• Density: 1.32g/cm³
• LogP: 2.39890
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 142.0297759
• Heavy Atom Count: 9
• Complexity: 79.1

Purity/Quality:

99.9% ^*data from raw suppliers

(4-Chlorophenyl)hydrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1NN)Cl

Technology Process of 4-Chlorophenylhydrazine

There total 30 articles about 4-Chlorophenylhydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-chloro-aniline (106-47-8) → N-4-chlorophenylhydrazine (1073-69-4)

Guidance literature:

With hydrazine hydro-chloride; In ethylene glycol; at 110 ℃; for 5h; Temperature; Reflux;

Reference yield: 78.0%

4-chloro-aniline (106-47-8) + butan-1-ol (71-36-3) → N-4-chlorophenylhydrazine (1073-69-4)

Guidance literature:

With hydrogenchloride; sodium hydroxide; sodium hydrogen sulfate; sodium nitrite;

Reference yield: 63.0%

p-chlorobenzenediazonium tetrafluoroborate (673-41-6) → N-4-chlorophenylhydrazine (1073-69-4)

Guidance literature:

With borohydride exchange resin; In methanol; at 0 ℃;

DOI:10.1080/00397919708003336

upstream raw materials:

N-chloro-N'-phenyl-urea

p-chlorobenzenediazonium chloride

4-chloro-aniline

p-chlorobenzenediazonium tetrafluoroborate

Downstream raw materials:

1-(4-chlorophenyl)-3-methyl-3-pyrazolin-5-one

1-(4-chloro-phenyl)-4,4-diphenyl semicarbazide

1(p-cloro)fenilazo-3,4,6,7,8,9-esaidrochinolizina

4-chloro-aniline

Refernces

• 1、 Tomakinian, Terry,Guillot, Régis,Kouklovsky, Cyrille,Vincent, Guillaume. "Synthesis of benzofuro[3,2-b] indoline amines via deamination-interrupted Fischer indolization and their unexpected reactivity towards nucleophiles". . p. 5443 - 5446. Retrieved 2016.
• 2、 Borate, Kailaskumar,Choi, Kyoungmin,Goetz, Roland,Hartwig, John F.,Shinde, Harish,Wang, Justin Y.,Zuend, Stephan J.. "Cross-Coupling between Hydrazine and Aryl Halides with Hydroxide Base at Low Loadings of Palladium by Rate-Determining Deprotonation of Bound Hydrazine". supporting information. p. 399 - 408. Retrieved 2020/10/29.
• 3、 -. "Method for synthesizing 1-(2,4-dichlorophenyl)-3-methyl-4-difluoromethyl-1,2,4-triazole-5-ketone". Paragraph 0056; 0057. . Retrieved 2018/03/28.