2,2'-Difluorodiphenyldisulfide

Base Information

• Chemical Name: 2,2'-Difluorodiphenyldisulfide
• CAS No.: 14135-38-7
• Molecular Formula: C12H8F2S2
• Molecular Weight: 254.324
• Hs Code.: 2930909090
• European Community (EC) Number: 821-542-1
• DSSTox Substance ID: DTXSID10563479
• Nikkaji Number: J3.435.896F
• Wikidata: Q72462892
• Mol file: 14135-38-7.mol

Synonyms:14135-38-7;2,2'-Difluorodiphenyldisulfide;2,2'-Difluoro diphenyl disulfide;1,2-Bis(2-fluorophenyl)disulfane;1-FLUORO-2-[(2-FLUOROPHENYL)DISULFANYL]BENZENE;Disulfide, bis(2-fluorophenyl);2,2/'-DIFLUORO DIPHENYL DISULFIDE;2,2'-Difluorodiphenyl disulfide;Disulfide, bis(fluorophenyl);bis-(2-fluorophenyl)disulfide;1,1'-dithiobis(2-fluorobenzene);SCHEMBL576534;4-(4-Butylphenyl)cyclohexanone;DTXSID10563479;MFCD09029446;AKOS015898606;DS-2281;1,1'-Disulfanediylbis(2-fluorobenzene);2 pound not2'-Difluorodiphenyldisulfide;AC-16465;CS-0156629;J-506789

Chemical Property of 2,2'-Difluorodiphenyldisulfide

Chemical Property:

• Boiling Point: 292.18 °C at 760 mmHg
• Flash Point: 130.506 °C
• PSA: 50.60000
• Density: 1.353g/cm³
• LogP: 4.76420
• Storage Temp.: 2-8°C
• XLogP3: 4.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 254.00354893
• Heavy Atom Count: 16
• Complexity: 191

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,2''-Difluorodiphenyldisulfide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)F)SSC2=CC=CC=C2F
• Uses: 2,2''-Difluoro diphenyl disulfide

Technology Process of 2,2'-Difluorodiphenyldisulfide

There total 8 articles about 2,2'-Difluorodiphenyldisulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-fluorothiophenol (2557-78-0) → bis(2-fluorophenyl) disulfide (14135-38-7)

Guidance literature:

With N,N,N,N,-tetramethylethylenediamine; oxygen; eosin y; In ethanol; for 0.333333h; Irradiation;

DOI:10.1002/adsc.201401010

Reference yield: 87.0%

2-fluorothiophenol (2557-78-0) → bis(2-fluorophenyl) disulfide (14135-38-7) + p,p'-Di-fluor-phenylsulfonylthiophenol

Guidance literature:

With aluminum dihydrogen phosphate; nitric acid; In acetonitrile; at 85 ℃; for 24h;

DOI:10.1016/j.bioorg.2020.104017

Reference yield: 69.0%

2-fluorothiophenol (2557-78-0) + 2-amino-benzenethiol (137-07-5) → bis(2-fluorophenyl) disulfide (14135-38-7) + 2-((2-fluorophenyl)disulfaneyl)aniline + 2-Aminophenyl disulfide (1141-88-4)

Guidance literature:

2-fluorothiophenol; 2-amino-benzenethiol; With dmap; water; In ethanol; at 20 ℃; for 0.0833333h;

With iodine; In ethanol; at 70 ℃; for 3h; Sealed tube;

DOI:10.1002/asia.201900620

upstream raw materials:

o-fluorophenylmercuric chloride

2-fluorothiophenol

1-Fluoro-2-iodobenzene

2-fluorobenzenediazonium tetrafluoroborate

Downstream raw materials:

C₂₁H₁₉ClF₄N₂O₃S₂

C₂₁H₁₉ClF₄N₂O₃S₂

C₂₁H₁₉ClF₄N₂O₃S₂

4-bromo-2-fluoro-1-[(2-fluorophenyl)thio]benzene

Refernces

• 1、 Bai, Ruoli,Barbosa, Euzébio Guimar?es,Beatriz, Adilson,Hamel, Ernest,Khodyuk, Rejane Gon?alves Diniz,Louren?o, Estela Mariana Guimar?es,de Lima, Dênis Pires,dos Santos, Edson dos Anjos. "Diaryl disulfides and thiosulfonates as combretastatin A-4 analogues: Synthesis, cytotoxicity and antitubulin activity". . . Retrieved 2020/07/07.
• 2、 Li, Xing,Du, Jia,Zhang, Yongli,Chang, Honghong,Gao, Wenchao,Wei, Wenlong. "Synthesis and nano-Pd catalyzed chemoselective oxidation of symmetrical and unsymmetrical sulfides". . p. 3048 - 3055. Retrieved 2019/03/21.