Ziprasidone hydrochloride monohydrate

Base Information

• Chemical Name: Ziprasidone hydrochloride monohydrate
• CAS No.: 138982-67-9
• Molecular Formula: C21H21ClN4OS.HCl.H2O
• Molecular Weight: 467.39
• Hs Code.: 38220010
• European Community (EC) Number: 638-781-0
• UNII: 216X081ORU
• DSSTox Substance ID: DTXSID00160855
• Wikidata: Q27114865
• NCI Thesaurus Code: C48031
• RXCUI: 1294533
• ChEMBL ID: CHEMBL1375743
• Mol file: 138982-67-9.mol

Synonyms:5-(2-(4-(3-benzisothiazolyl)piperazinyl)ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one;CP 88059;CP 88059-01;CP-88,059;CP-88,059-01;CP-88,059-1;Geodon;ziprasidone;ziprasidone hydrochloride;ziprasidone hydrochloride, monohydrate;ziprazidone

Chemical Property of Ziprasidone hydrochloride monohydrate

Chemical Property:

• Appearance/Colour: off-white powder
• Vapor Pressure: 2.38E-12mmHg at 25°C
• Melting Point: 300 °C
• Boiling Point: 554.8 °C at 760 mmHg
• Flash Point: 289.3 °C
• PSA: 85.94000
• LogP: 4.68760
• Storage Temp.: Room temp
• Solubility.: DMSO: >10mg/mL
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 4
• Exact Mass: 466.0997026
• Heavy Atom Count: 30
• Complexity: 573

Purity/Quality:

99% ^*data from raw suppliers

Ziprasidone hydrochloride monohydrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Safety Statements: 24/25

MSDS Files:

Useful:

• Canonical SMILES: C1CN(CCN1CCC2=C(C=C3C(=C2)CC(=O)N3)Cl)C4=NSC5=CC=CC=C54.O.Cl
• Recent ClinicalTrials: A Six-week Flexible Dose Study Evaluating the Efficacy and Safety of Geodon in Patients With Bipolar I Depression.
• Recent EU Clinical Trials: Pharmacovigilance in children and adolescents:
• Uses: Combined serotonin (5HT2) and dopamine (D2) receptor antagonist. Used as an antipsychotic. antipsychotic;Dopamine D2/serotonin 5-HT2 antagonist Ziprasidone Hydrochloride is the hydrochloride salt of a benzisothiazolylpiperazine analog structurally related to the atypical antipsychotic drug tiospirone that antagonizes both central serotonin 5-HT2A (Ki = 0.42 nM) and dopamine D2 (Ki = 4.8 nM) receptors. It is also a potent agonist at 5-HT1A receptors (Ki = 3.4 nM), increasing cortical dopamine release which may offset negative effects associated with dopamine D2 antagonism, and an inverse agonist at 5-HT1B and 5-HT1D receptors (pKis = 8.8 and 8.6, respectively).[Cayman Chemical]