L-Homophenylalanine hydrochloride

Base Information

• Chemical Name: L-Homophenylalanine hydrochloride
• CAS No.: 105382-09-0
• Molecular Formula: C₁₀H₁₃NO₂*ClH
• Molecular Weight: 215.68
• Hs Code.: 2922499990
• Mol file: 105382-09-0.mol

Synonyms:Benzenebutanoicacid, a-amino-, hydrochloride, (S)-;Benzenebutanoic acid, a-amino-, hydrochloride, (aS)- (9CI);

Chemical Property of L-Homophenylalanine hydrochloride

Chemical Property:

• Vapor Pressure: 9.79E-05mmHg at 25°C
• Melting Point: 262-265 °C (dec.)(lit.)
• Boiling Point: 324.8 °C at 760 mmHg
• Flash Point: 150.2 °C
• PSA: 63.32000
• LogP: 2.53340
• Storage Temp.: Store at RT.

Purity/Quality:

99% ^*data from raw suppliers

L-Homophenylalanine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: L-Homophenylalanine, HCl

Technology Process of L-Homophenylalanine hydrochloride

There total 25 articles about L-Homophenylalanine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(R)-tert-butyl 2-amino-4-phenylbutanoate (740055-30-5) → (R)-2-amino-4-phenylbutanoic acid hydrochloride (105382-09-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 100 ℃; for 12h;

DOI:10.1021/ol302427d

Reference yield: 99.0%

(R)-ethyl 2-amino-4-phenylbutanoate (124044-66-2) → (R)-2-amino-4-phenylbutanoic acid hydrochloride (105382-09-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 80 ℃;

DOI:10.1021/ja8018934

Reference yield: 99.0%

methyl 4-phenyl-2-(2,2,2-trifluoroacetamido)butanoate (1088806-73-8) → L-(+)-homophenylalanine hydrochloride (105382-09-0)

Guidance literature:

With hydrogenchloride; water; at 80 ℃; for 6h;

DOI:10.1016/j.tetlet.2008.09.013

upstream raw materials:

1-phenyl-2-bromoethane

2-acetylaminomalonic acid diethyl ester

tert-butyl 1-hydroxy-3-phenylpropan-2-ylcarbamate

methanesulfonyl chloride

Downstream raw materials:

2-(RS)-(2-aminobenzoylamino)-4-phenylbutyric acid ethyl ester

2-(RS)-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}-4-phenylbutyric acid ethyl ester

(RS)-1H-indol-2-carboxylic acid 2-(1-hydroxycarbamoyl-3-phenylpropylcarbamoyl)phenylamide

(RS)-1H-indole-2-carboxylic acid [2-(1-carbamoyl-3-phenylpropylcarbamoyl)phenyl]amide

Refernces

• 1、 Xiao, Xiao,Liu, Mao,Rong, Chao,Xue, Fazhen,Li, Songlei,Xie, Ying,Shi, Yian. "An efficient asymmetric biomimetic transamination of α-keto esters to chiral α-amino esters". supporting information. p. 5270 - 5273. Retrieved 2013/01/15.
• 2、 Murashige, Ryo,Hayashi, Yuka,Hashimoto, Makoto. "Asymmetric and efficient synthesis of homophenylalanine derivatives via Friedel-Crafts reaction with trifluoromethanesulfonic acid". supporting information; scheme or table. p. 6566 - 6568. Retrieved 2009/04/05.