Dimethyl(3-triphenylphosphaniumylpropyl)azanium;dibromide

Base Information

• Chemical Name: Dimethyl(3-triphenylphosphaniumylpropyl)azanium;dibromide
• CAS No.: 27710-82-3
• Molecular Formula: C23H28Br2NP
• Molecular Weight: 509.264
• Hs Code.: 2931900090
• Mol file: 27710-82-3.mol

Synonyms:dimethyl(3-triphenylphosphaniumylpropyl)azanium;dibromide;AKOS005067831

Chemical Property of Dimethyl(3-triphenylphosphaniumylpropyl)azanium;dibromide

Chemical Property:

• Melting Point: 283-285 °C
• PSA: 16.83000
• LogP: 1.89430
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 7
• Exact Mass: 509.03056
• Heavy Atom Count: 27
• Complexity: 317

Purity/Quality:

99% ^*data from raw suppliers

[3-(Dimethylamino)propyl]triphenylphosphoniumBromideHydrobromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[NH+](C)CCC[P+](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3.[Br-].[Br-]
• Uses: (3-(Dimethylamino)propyl)triphenylphosphonium bromide is used as a reactant for preparing chlorpheniramine analogs reverse chloroquine resistance in Plasmodium falciparum by inhibiting PfCRT.

Technology Process of Dimethyl(3-triphenylphosphaniumylpropyl)azanium;dibromide

There total 2 articles about Dimethyl(3-triphenylphosphaniumylpropyl)azanium;dibromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.4%

3-bromopropyltriphenylphosphonium bromide (3607-17-8) + dimethyl amine (124-40-3) → anhydrous 3-(dimethylamino)propyltriphenylphosphonium bromide hydrobromide (27710-82-3)

Guidance literature:

In ethanol; Temperature; Reflux;

Reference yield:

→ anhydrous 3-(dimethylamino)propyltriphenylphosphonium bromide hydrobromide (27710-82-3)

Guidance literature:

Reference yield: 99.0%

(11-oxo-6,11-dihydro-dibenzo[b,e]oxepin-2-yl)-acetic acid benzyl ester (60548-16-5) + anhydrous 3-(dimethylamino)propyltriphenylphosphonium bromide hydrobromide (27710-82-3) → (E )-11-[ 3-(dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid hydrochloride (949141-22-4) + olopatadine hydrochloride (140462-76-6)

Guidance literature:

anhydrous 3-(dimethylamino)propyltriphenylphosphonium bromide hydrobromide; With sodium hydride; In tetrahydrofuran; for 3h; Heating / reflux;

(11-oxo-6,11-dihydro-dibenzo[b,e]oxepin-2-yl)-acetic acid benzyl ester; In tetrahydrofuran; at 0 - 30 ℃; for 3h;

With hydrogenchloride; water; In di-isopropyl ether; pH=2;

upstream raw materials:

3-bromopropyltriphenylphosphonium bromide

dimethyl amine

Downstream raw materials:

(Z)-11-<3-(dimethylamino)propylidene>-6,11-dihydrodibenzoxepin-2-carboxylic acid methyl ester

(E)-11-<3-(dimethylamino)propylidene>-6,11-dihydrodibenzoxepin-2-carboxylic acid methyl ester

{(5R)-5-[(2R,4Z)-2-(benzyloxy)-7-(dimethylamino)hept-4-enyl]tetrahydrofuran-2-yl}acetonitrile

[4-(4-bromo-phenyl)-butyl]-dimethyl-amine

Refernces

• 1、 -. "HYDROXYLATED TRICYCLIC COMPOUNDS". Page/Page column 68. . Retrieved 2012/06/30.
• 2、 -. "DIBENZ[B,E]OXEPIN DERIVATIVE AND PHARMACEUTICAL COMPOSITIONS THEREOF". . . Retrieved 2008/06/13.