2-Bromo-4-fluoroaniline

Base Information

• Chemical Name: 2-Bromo-4-fluoroaniline
• CAS No.: 1003-98-1
• Molecular Formula: C6H5BrFN
• Molecular Weight: 190.015
• Hs Code.: 29214200
• Mol file: 1003-98-1.mol

Synonyms:2-bromo-4-fluoro-aniline;2-Bromo-4-Fluoro Aniline;2-Bromo-4-fluoro-phenylamine;Bromofluoroaniline1;2-Bromo-4-fluoroaniline 99%;2-Bromo-4-fluoroaniline 98+%;Benzenamine, 2-bromo-4-fluoro-;

Chemical Property of 2-Bromo-4-fluoroaniline

Chemical Property:

• Appearance/Colour: Clear yellow-brown liquid
• Vapor Pressure: 0.0743mmHg at 25°C
• Melting Point: 41 °C
• Refractive Index: n20/D 1.583(lit.)
• Boiling Point: 221 °C at 760 mmHg
• PKA: 2.60±0.10(Predicted)
• Flash Point: 104.4 °C
• PSA: 26.02000
• Density: 1.694 g/cm³
• LogP: 2.75160
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99% ^*data from raw suppliers

2-Bromo-4-fluoroaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,T
• Hazard Codes: Xi,T
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromo-4-fluoroaniline

There total 6 articles about 2-Bromo-4-fluoroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-fluoroaniline (371-40-4) → 2-bromo-4-fluoroaniline (1003-98-1)

Guidance literature:

With N-Bromosuccinimide; In dichloromethane; at 0 - 5 ℃; Schlenk technique; Inert atmosphere;

DOI:10.1039/c9ob00615j

Reference yield:

4'-fluoroacetanilide (351-83-7) → 2-bromo-4-fluoroaniline (1003-98-1)

Guidance literature:

With bromine; In acetic acid;

DOI:10.1021/jo01042a006

Reference yield:

→ 2-bromo-4-fluoroaniline (1003-98-1)

Guidance literature:

p-Fluor-anilin, N-Brom-succinimid;

upstream raw materials:

4'-fluoroacetanilide

4-fluoroaniline

N-(2-bromophenyl)-N-hydroxyacetamide

N-(2-bromo-4-fluorophenyl)acetamide

Downstream raw materials:

4-(N,N-dimethylaminophenyl)-(4'-fluoro-2'-bromo)azomethine

(2-amino-5-fluorophenyl)phosphonate de diethyle

4-fluoroaniline

C₁₆H₂₁BrFNO₄

Refernces

• 1、 Takahashi, Yusuke,Seki, Masahiko. "A Practical Procedure for Regioselective Bromination of Anilines". . p. 1828 - 1832. Retrieved 2021.
• 2、 Durka, Krzysztof,Laudy, Agnieszka E.,Charzewski, ?ukasz,Urban, Mateusz,St?pień, Karolina,Tyski, Stefan,Krzy?ko, Krystiana A.,Luliński, Sergiusz. "Antimicrobial and KPC/AmpC inhibitory activity of functionalized benzosiloxaboroles". . p. 11 - 24. Retrieved 2019.
• 3、 -. "4 - Fluorine substituted aryl amine compound and synthesis method thereof". . . Retrieved 2021/09/22.