Secretin (pig)

Base Information

• Chemical Name: Secretin (pig)
• CAS No.: 17034-35-4
• Deprecated CAS: 26048-84-0,27506-32-7
• Molecular Formula: C130H220N44O41
• Molecular Weight: 3055.45
• ChEMBL ID: CHEMBL3245432
• Mol file: 17034-35-4.mol

Synonyms:3-beta-Asp-secretin;beta-aspartoyl(3)-secretin;secretin, beta-Asp(3)-;secretin, beta-aspartic acid(3)-

Chemical Property of Secretin (pig)

Chemical Property:

• Appearance/Colour: powder
• PSA: 1421.45000
• Density: 1.50±0.1 g/cm3(Predicted)
• LogP: -0.31500
• Storage Temp.: 2-8°C
• Solubility.: H2O: soluble
• XLogP3: -14.1
• Hydrogen Bond Donor Count: 52
• Hydrogen Bond Acceptor Count: 47
• Rotatable Bond Count: 109
• Exact Mass: 3054.6516174
• Heavy Atom Count: 215
• Complexity: 6980

Purity/Quality:

99% ^*data from raw suppliers

Secretin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)CC(C(=O)NC(C(C)C)C(=O)N)NC(=O)CNC(=O)C(CCC(=O)N)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCC(=O)N)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(C)NC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCC(=O)O)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(C(C)O)NC(=O)CNC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C(CC2=CN=CN2)N
• Isomeric SMILES: C[C@H]([C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N)NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC2=CN=CN2)N)O
• Recent EU Clinical Trials: The Effects of Dietary Peptides on Human Brown Adipose Tissue
• Biological functions: Using northern blotting analysis, human SCTR mRNA was detected in the pancreas, intestine, colon, kidney, lung, and liver. Secretin stimulates the secretion of bicarbonate, water, and electrolytes from the ductal epithelium. In the stomach, secretin acts as an enterogastrone that inhibits gastric acid release and gastric emptying. In the kidney, secretin regulates urine output and activates adenylyl cyclase in rats. In the brain, SCTR is widely distributed in the hippocampus, central amygdala, thalamus, hypothalamus, posterior pituitary, cerebellum, and medulla oblongata. Secretin regulates social interaction, water and food intake, motor coordination, and spatial and motor learning behaviors. The zebrafish secretin receptor has been shown to be nonbioactive.
• Description: Secretin was the first hormone identified. It is a secretagogue of pancreatic digestive juices from the porcine duodenum, used to aid in the diagnosis of gastrinoma. Secretin was discovered by Bayliss and Starling in 1902 as a secretagogue of pancreatic juices from the porcine duodenum. It was the first hormone identified.
• Clinical Use: Recombinant human secretin (SecreFlo, ChiRhoStim) is approved for use in stimulating gastrin secretion to aid in the diagnosis of gastrinoma.

Technology Process of Secretin (pig)

There total 1 articles about Secretin (pig) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ secretin (pig) (17034-35-4)

Guidance literature:

nach konventionellen Methoden, letzte Stufe Abspaltung der Schutzgruppen aus Z-His-Ser(CH2-Ph)-Asp(OCH2-Ph)-Gly-Thr-Phe-Thr-Ser(CH2-Ph)-Glu(OCH2-Ph)-Leu-Ser(CH2-Ph)-Arg(NO2)-Leu-Arg(NO2)-Asp(OCH2-Ph)-Ser(CH2-Ph)-Ala-Arg(NO2)-Leu-Glu(NH2)-;

Refernces

• 1、 Ondetti,Narayanan,von Saltza,Sheehan,Sabo,Bodanszky. "The synthesis of secretin. 3. The fragment-condensation approach.". . p. 4711 - 4715. Retrieved 2007/10/06.