Fortical

Base Information

• Chemical Name: Fortical
• CAS No.: 47931-85-1
• Molecular Formula: C145H240N44O48S2
• Molecular Weight: 3431.85
• Hs Code.: 2937190000
• European Community (EC) Number: 232-693-2
• RXCUI: 36118
• Wikipedia: Calcitonin
• Mol file: 47931-85-1.mol

Synonyms:Calcihexal;Calcimar;calcitonin salmon;Forcaltonin;Fortical;Miacalcic;Miacalcin;recombinant salmon calcitonin;salcatonin;salmon calcitonin;salmon calcitonin (1-32);synthetic salmon calcitonin;Calcitonin;Calcitonin(1-32);Calcitonin, Eel;Calcitrin;Ciba 47175 BA;Ciba 47175-BA;Ciba 47175BA;Eel Calcitonin;Thyrocalcitonin

Chemical Property of Fortical

Chemical Property:

• Appearance/Colour: powder
• Refractive Index: 1.676
• PSA: 1558.81000
• Density: 1.54±0.1 g/cm3(Predicted)
• LogP: -3.89630
• Storage Temp.: −20°C
• Solubility.: 0.05 M acetic acid: 1 mg/mL, clear, colorless
• Water Solubility.: Soluble in water at 1mg/ml
• XLogP3: -16.6
• Hydrogen Bond Donor Count: 52
• Hydrogen Bond Acceptor Count: 55
• Rotatable Bond Count: 99
• Exact Mass: 3430.7166627
• Heavy Atom Count: 239
• Complexity: 7970

Purity/Quality:

98% ^*data from raw suppliers

Salmon Calcitonin ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)CC1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)N)CO)N)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(CC2=CN=CN2)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)N)C(=O)NC(C(C)O)C(=O)NC(CC3=CC=C(C=C3)O)C(=O)N4CCCC4C(=O)NC(CCCNC(=N)N)C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)O)C(=O)NCC(=O)NC(CO)C(=O)NCC(=O)NC(C(C)O)C(=O)N5CCCC5C(=O)N)C(C)O)CO
• Recent ClinicalTrials: Efficacy and Safety of Oral Salmon Calcitonin in Patients With Knee Osteoarthritis (OA 2 Study)
• Recent EU Clinical Trials: A Randomized, Double-Blind, Multi-Center, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Oral Salmon Calcitonin in the Treatment of Subjects with Knee Osteoarthritis.
• Description: Calcitonin Salmon is a polypeptide hormone secreted by the ultimobranchial gland of salmon. It belongs to the calcitonin-like protein family and can be used to treat Paget's disease of bone, postmenopausal osteoporosis(fragile or brittle bones), or high levels of calcium in the blood (hypercalcemia). It appears to have actions essentially identical to calcitonins of mammalian origin, but its potency per mg is greater and it has a longer duration of action. It works mainly by Inhibiting osteoclastic bone resorption, decreasing serum calcium, and increasing renal excretion of phosphate, calcium, sodium magnesium and potassium by decreasing tubular reabsorption. Calcitonin is a single-chain polypeptide consisting of 32 amino acid residues. Calcitonins as obtained from different species are identical at seven of the first nine residues, contain Gly at position 28, and all terminate with Pro-NH2. The C-terminal proline amide (ProNH2) is very important for the biological function of CT, as is the disulfide bridge between Cys residues at positions 1 and 7. In contrast, the residues from 10 through 27 can be varied and seem to influence CT's potency as well as its duration of action. Salmon CT differs from human CT at 16 amino acid residues.
• Uses: Osteoporosis;Hypercalcemia; Paget’s disease ; Reflex sympathetic dystrophy (algodistrophy or Sudeck’s disease) Calcitonin salmon can be used for calcitonin receptor/cAMP assay for assessing the presence of calcitonin receptors expressed by TRAP+ cells.The product can also be used as a test compound for studying as well as comparing the impact of calcitonin gene related peptide (CGRP) and salmon calcitonin (sCT) on gastric mucosal barrier in rats exposed to cold + restraint stress (CRS).
• Clinical Use: Only salmon CT is commercially available for medical use, because on a weight basis, it is approximately 45-fold more potent than human CT. Salmon CT, in parenteral form, is approved for treating Paget's disease of bone (generally seen in older persons; involves increased bone resorption and softening of bones), postmenopausal osteoporosis, and hypercalcemia of malignancy (multiple myeloma or advanced breast carcinoma). Salmon CT also is available in a nasal spray formulation, which is used exclusively in the treatment of postmenopausal osteoporosis.