Betahistine Hydrochloride

Base Information

• Chemical Name: Betahistine Hydrochloride
• CAS No.: 15430-48-5
• Molecular Formula: C₈H₁₂N₂*2ClH
• Molecular Weight: 209.119
• Hs Code.: 2933399090
• Mol file: 15430-48-5.mol

Synonyms:Pyridine,2-[2-(methylamino)ethyl]-, monohydrochloride (8CI); 2-(b-Methylaminoethyl)pyridinehydrochloride; Betahistine monohydrochloride;N-Methyl-N-(2-(2-pyridinyl)ethyl)amine hydrochloride; b-(2-Pyridyl)ethyl methyl aminehydrochloride

Chemical Property of Betahistine Hydrochloride

Chemical Property:

• Vapor Pressure: 0.187mmHg at 25°C
• Boiling Point: 210.9°Cat760mmHg
• Flash Point: 96.7°C
• PSA: 24.92000
• Density: g/cm³
• LogP: 2.03640
• Storage Temp.: Hygroscopic, Store under Inert atmosphere Refrigerator

Purity/Quality:

98%Min ^*data from raw suppliers

Betahistine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Betahistine is most commonly used to treat the symptoms of Mie disease and vertigo. Vasodilator Betahistine Hydrochloride is most commonly used to treat the symptoms of Ménière's disease and vertigo.

Technology Process of Betahistine Hydrochloride

There total 8 articles about Betahistine Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.5%

2-(2-Hydroxyethyl)pyridine (103-74-2) + methylamine hydrochloride (593-51-1) → betahistine hydrochloride (15430-48-5)

Guidance literature:

2-(2-Hydroxyethyl)pyridine; methylamine hydrochloride; With palladium/alumina; sodium hydrogencarbonate; In chlorobenzene; at 130 ℃; for 12h;

With hydrogenchloride; In ethanol; water; for 2h; Reagent/catalyst; Temperature; Solvent;

Reference yield: 94.1%

2-(2-Hydroxyethyl)pyridine (103-74-2) + methylamine (74-89-5) → betahistine hydrochloride (15430-48-5)

Guidance literature:

2-(2-Hydroxyethyl)pyridine; methylamine; With Pd/C; potassium hydroxide; In 5,5-dimethyl-1,3-cyclohexadiene; water; at 140 ℃; for 10h;

With hydrogenchloride; In ethanol; water; for 2h; Reagent/catalyst; Solvent; Temperature;

Reference yield: 68.0%

2-(pyridin-2-yl)ethyl methanesulfonate (138428-37-2) + methylamine (74-89-5) → betahistine hydrochloride (15430-48-5)

Guidance literature:

2-(pyridin-2-yl)ethyl methanesulfonate; methylamine; In water; acetonitrile; at 140 ℃; for 0.166667h; under 15514.9 Torr; Flow reactor;

With hydrogenchloride; In 1,4-dioxane; diethyl ether;

DOI:10.1021/acs.oprd.0c00193

upstream raw materials:

betahistine

α-picoline

2-(2-Hydroxyethyl)pyridine

2-vinylpyridine

Refernces

• 1、 -. "Synthesis method of betahistine hydrochloride". Paragraph 0029; 0030; 0033; 0034; 0037-0040; 0047-0052. . Retrieved 2021/11/19.
• 2、 -. "Preparation method of orthographic optimizing betahistine hydrochloride". Paragraph 0009. . Retrieved 2018/07/30.