Epipodophyllotoxin

Base Information Edit

Chemical Name:Epipodophyllotoxin
CAS No.:4375-07-9
Molecular Formula:C22H22 O8
Molecular Weight:414.412
Hs Code.:
DSSTox Substance ID:DTXSID10859440
Nikkaji Number:J5.172A
Wikipedia:Epipodophyllotoxin
Wikidata:Q3589174
ChEMBL ID:CHEMBL282256
Mol file:4375-07-9.mol

Synonyms:Condyline;Condylox;CPH86;Epipodophyllotoxin;Podocon-25;Podofilm;Podofilox;Podophyllotoxin;Podophyllotoxin, (5R-(5 alpha,5a alpha,8a alpha,9 alpha))-Isomer;Podophyllotoxin, (5R-(5 alpha,5a alpha,8a alpha,9 beta))-Isomer;Podophyllotoxin, (5R-(5 alpha,5a alpha,8a beta,9 alpha))-Isomer;Podophyllotoxin, (5R-(5 alpha,5a beta,8a alpha,9 beta))-Isomer;Wartec;Warticon

Suppliers and Price of Epipodophyllotoxin

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Epipodophyllotoxin
1g
$ 1190.00

Total 18 raw suppliers

Chemical Property of Epipodophyllotoxin Edit

Chemical Property:

Melting Point:160.3°C
Refractive Index:1.4480 (estimate)
Boiling Point:453.31°C (rough estimate)
PKA:13.26±0.40(Predicted)
Flash Point:210.2oC
PSA：92.68000
Density:1.2649 (rough estimate)
LogP:2.40920
Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility.:Chloroform (Slightly), Methanol (Slightly)
XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:4
Exact Mass:414.13146766
Heavy Atom Count:30
Complexity:629

Purity/Quality:

99%, ^*data from raw suppliers

Epipodophyllotoxin ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC(=CC(=C1OC)OC)C2C3C(COC3=O)C(C4=CC5=C(C=C24)OCO5)O
Isomeric SMILES:COC1=CC(=CC(=C1OC)OC)[C@H]2[C@@H]3[C@H](COC3=O)[C@@H](C4=CC5=C(C=C24)OCO5)O
Recent EU Clinical Trials:A Study of Thiotepa, Ifosphamide, Etoposide and Rituximab for the treatment of relapsed or refractory primary central nervous system lymphoma
Uses Epipodophyllotoxins is a naturally occuring antitumors agent extracted from Mayapple plant.

Technology Process of Epipodophyllotoxin

There total 154 articles about Epipodophyllotoxin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 477-51-0,6258-33-9,17187-81-4,17301-90-5,19186-35-7,24150-39-8,31892-96-3,55568-81-5,64550-41-0,69222-20-4,75171-57-2,83023-41-0,100348-38-7
deoxypodophyllotoxin

: 4375-07-9
epipodophyllotoxin

Guidance literature:: With resting cells of Penicillian F-0543; In ethanol; water; for 168h;

Reference yield: 98.0%

: 4375-06-8
epipicropodophyllotoxin

: 4375-07-9
epipodophyllotoxin

Guidance literature:: With 4 A molecular sieve; zinc(II) chloride; In tetrahydrofuran; at 66 ℃; for 12h;
DOI:10.1002/anie.200351086

Reference yield: 95.0%

: 518-28-5
podofilox

: 4375-07-9
epipodophyllotoxin

Guidance literature:: podofilox; With methanesulfonic acid; sodium bromide; In acetonitrile; at 20 ℃; for 1h; Inert atmosphere; Green chemistry;

With barium carbonate; In water; at 20 ℃; Green chemistry;