Solumedine

Base Information

• Chemical Name: Solumedine
• CAS No.: 127-58-2
• Molecular Formula: C11H11N4NaO2S
• Molecular Weight: 287.32
• NSC Number: 226823
• Mol file: 127-58-2.mol

Synonyms:Solumedine;Monosodium 2-sulfanilamido-4-methylpyrimidine;2-Sulfanilamido-4-methylpyrimidine sodium salt;4-Methyl-2-sulfanilamidopyrimidine sodium salt;Sulfamerazine sodium, injection;NSC226823

Chemical Property of Solumedine

Chemical Property:

• Vapor Pressure: 7.03E-11mmHg at 25°C
• Melting Point: 216-219 °C
• Boiling Point: 519.1 °C at 760 mmHg
• Flash Point: 267.8 °C
• PSA: 97.56000
• LogP: 2.68880
• Water Solubility.: Soluble in DMSO or water
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 3
• Exact Mass: 287.05786609
• Heavy Atom Count: 19
• Complexity: 360

Purity/Quality:

99% ^*data from raw suppliers

Sulfamerazine sodium salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi
• Hazard Codes: Xn,Xi
• Statements: 20/22-36/38-36/37/38
• Safety Statements: 7-24-45-36-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC(=NC=C1)NS(=O)(=O)C2=CC=C(C=C2)N.[Na+]
• Description: Sulfamerazine is a sulfonamide antibiotic. It inhibits bacterial carbonic anhydrase by ~20% at a concentration of 500 μM. In vivo, sulfamerazine (500 mg/L) reduces severity of peribronchitis and inhibits cilia-associated respiratory Bacillus colonization in mice. It also prevents death of Toxoplasma-infected mice. Sulfonamide class antibiotics, of which sulfamerazine is a member, are bacteriostatic and inhibit bacterial synthesis of dihydrofolic acid by competing with 4-aminobenzoic acid for binding to dihydropteroate synthase. Formulations containing sulfamerazine have been used for the treatment of pneumonia and typhoid fever.
• Uses: Involved in characterization of chirosan membranes for the transport of drugs Involved in characterization of chirosan membranes for the transport of drugs1,2,3