2-PYRIMIDINAMINE, 4-(3,4-DIHYDRO-1-METHYL-2(1H)-ISOQUINOLINYL)-N-(4-FLUOROPHENYL)-5,6-DIMETHYL-, MONOHYDROCHLORIDE

Base Information

• Chemical Name: 2-PYRIMIDINAMINE, 4-(3,4-DIHYDRO-1-METHYL-2(1H)-ISOQUINOLINYL)-N-(4-FLUOROPHENYL)-5,6-DIMETHYL-, MONOHYDROCHLORIDE
• CAS No.: 178307-42-1
• Molecular Formula: C₂₂H₂₃FN₄*ClH
• Molecular Weight: 398.911
• Mol file: 178307-42-1.mol

Synonyms:2-Pyrimidinamine,4-(3,4-dihydro-1-methyl-2(1H)-isoquinolinyl)-N-(4-fluorophenyl)-5,6-dimethyl-,monohydrochloride (9CI);5,6-dimethyl-2-(4-fluorophenylamino)-4-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidinehydrochloride;SB 641257 hydrochloride;SB 641257A;YH 1885;

Chemical Property of 2-PYRIMIDINAMINE, 4-(3,4-DIHYDRO-1-METHYL-2(1H)-ISOQUINOLINYL)-N-(4-FLUOROPHENYL)-5,6-DIMETHYL-, MONOHYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 1.53E-12mmHg at 25°C
• Melting Point: 205-208°
• Boiling Point: 559.3 °C at 760 mmHg
• Flash Point: 292.1 °C
• PSA: 41.05000
• LogP: 6.03980

Purity/Quality:

99% ^*data from raw suppliers

RevaprazanHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Gastric proton pump inhibitor. Antiulcerative.

Technology Process of 2-PYRIMIDINAMINE, 4-(3,4-DIHYDRO-1-METHYL-2(1H)-ISOQUINOLINYL)-N-(4-FLUOROPHENYL)-5,6-DIMETHYL-, MONOHYDROCHLORIDE

There total 6 articles about 2-PYRIMIDINAMINE, 4-(3,4-DIHYDRO-1-METHYL-2(1H)-ISOQUINOLINYL)-N-(4-FLUOROPHENYL)-5,6-DIMETHYL-, MONOHYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.53%

→ Revaprazan hydrochloride (178307-42-1)

Guidance literature:

Reference yield: 62.4%

→ (R)-2-(4-fluoroaniline)-4-(1-methyl-1,2,3,4-tetrahydroisoquinoline-2-yl)-5,6-dimethylpyrimidine hydrochloride (178307-42-1)

Guidance literature:

Reference yield: 60.6%

→ (S)-2-(4-fluoroaniline)-4-(1-methyl-1,2,3,4-tetrahydroisoquinoline-2-yl)-5,6-dimethylpyrimidine hydrochloride (178307-42-1)

Guidance literature:

Refernces

• 1、 -. "Revaprazan hydrochloride impurities and preparation method thereof". . . Retrieved 2017/09/01.