(4-Carboxyanilino)azanium;chloride

Base Information

• Chemical Name: (4-Carboxyanilino)azanium;chloride
• CAS No.: 24589-77-3
• Molecular Formula: C₇H₈N₂O₂*ClH
• Molecular Weight: 188.614
• Hs Code.: 2928000090
• Mol file: 24589-77-3.mol

Synonyms:

Chemical Property of (4-Carboxyanilino)azanium;chloride

Chemical Property:

• Appearance/Colour: white to light yellow crystal powder
• Vapor Pressure: 2.32E-06mmHg at 25°C
• Melting Point: 253 °C (dec.)(lit.)
• Boiling Point: 377.2 °C at 760 mmHg
• Flash Point: 181.9 °C
• PSA: 75.35000
• LogP: 2.24570
• Storage Temp.: 2-8°C
• Water Solubility.: Soluble in water.
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 188.0352552
• Heavy Atom Count: 12
• Complexity: 141

Purity/Quality:

99% ^*data from raw suppliers

4-Hydrazinobenzoic acid hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C(=O)O)N[NH3+].[Cl-]
• Uses: 4-Hydrazinobenzoic acid hydrochloride is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff fields. It may be used for the preparation of 4-(3-(2-(tert-butoxycarbonylamino)ethyl)-5-hydroxy-1H-pyrazol-1-yl)benzoic acid.

Technology Process of (4-Carboxyanilino)azanium;chloride

There total 1 articles about (4-Carboxyanilino)azanium;chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) → 4-hydrazinobenzoic acid hydrochloride (24589-77-3,52455-33-1)

Guidance literature:

4-amino-benzoic acid; With magnesium nitrite; In water; at 2 ℃; Acidic conditions; Flow reactor;

With sodium sulfite; In water; at 99 - 120 ℃;

With hydrogenchloride; In water; at 120 ℃;

Reference yield: 100.0%

trimethylacetylacetonitrile (59997-51-2) + 4-hydrazinobenzoic acid hydrochloride (24589-77-3,52455-33-1) → 4-(5-amino-3-tert-butyl-1H-pyrazol-1-yl)benzoic acid (869663-56-9)

Guidance literature:

With hydrogenchloride; In ethanol; for 18h; Reflux;

Reference yield: 98.0%

3-methyl-butan-2-one (563-80-4) + 4-hydrazinobenzoic acid hydrochloride (24589-77-3,52455-33-1) → 2,3,3-trimethyl-5-carboxy-3H-indole (84100-84-5)

Guidance literature:

In acetic acid; for 12h; Reflux;

DOI:10.1021/ja910090v

upstream raw materials:

4-amino-benzoic acid

Downstream raw materials:

4-(4-phenyl-thiosemicarbazido)-benzoic acid

4-{N'-[3-Methyl-cyclohex-(Z)-ylidene]-hydrazino}-benzoic acid

4-(5,9-Dioxo-8,9-dihydro-5H-7-thia-10,11-diaza-cyclohepta[a]naphthalen-10-yl)-benzoic acid

4-(6-Methyl-5,9-dioxo-8,9-dihydro-5H-7-oxa-10,11-diaza-cyclohepta[a]naphthalen-10-yl)-benzoic acid

Refernces

• 1、 Zhang, Peng,Meng, Jiben,Li, Xiaoliu,Matsuura, Teruo,Wang, Yongmei. "Synthesis and photochromism of photochromic spiro compounds having a reactive pendant group". . p. 179 - 184. Retrieved 2002.
• 2、 Muralirajan, Krishnamoorthy,Cheng, Chien-Hong. "Regioselective synthesis of indoles via rhodium-catalyzed C-H activation directed by an in-situ generated redox-neutral group". . p. 1571 - 1576. Retrieved 2014/06/09.