Nicotine, tartrate (1:2), (-)-l-

Base Information

• Chemical Name: Nicotine, tartrate (1:2), (-)-l-
• CAS No.: 65-31-6
• Molecular Formula: 2C₄H₆O₆*C₁₀H₁₄N₂
• Molecular Weight: 462.411
• European Community (EC) Number: 200-607-2
• ICSC Number: 0521
• UN Number: 1659
• DSSTox Substance ID: DTXSID30931338
• Mol file: 65-31-6.mol

Synonyms:Nicotine, tartrate (1:2), (-)-l-;1421-32-5;DTXSID30931338;65-31-6;2,3-Dihydroxybutanedioic acid--3-(1-methylpyrrolidin-2-yl)pyridine (2/1);(2S,3S)-2,3-dihydroxybutanedioic acid;3-[(2S)-1-methylpyrrolidin-2-yl]pyridine

Chemical Property of Nicotine, tartrate (1:2), (-)-l-

Chemical Property:

• Appearance/Colour: A reddish white crystalline solid.
• Vapor Pressure: 0.0303mmHg at 25°C
• Melting Point: 89℃
• Boiling Point: 508℃(e)
• Flash Point: 101.7°C
• PSA: 246.25000
• LogP: -2.45900
• Storage Temp.: Desiccate at RT
• Solubility.: H2O: 50 mg/mL
• Water Solubility.: 1000000 mg l-1 (e)
• Hydrogen Bond Donor Count: 8
• Hydrogen Bond Acceptor Count: 14
• Rotatable Bond Count: 7
• Exact Mass: 462.14857427
• Heavy Atom Count: 32
• Complexity: 281
• Transport DOT Label: Poison

Purity/Quality:

99.9% ^*data from raw suppliers

(-)-NicotineDitartrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T+,N
• Hazard Codes: T+,N
• Statements: 26/27/28-51/53
• Safety Statements: 13-28-45-61

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Biological Agents -> Plant Toxins
• Canonical SMILES: CN1CCCC1C2=CN=CC=C2.C(C(C(=O)O)O)(C(=O)O)O.C(C(C(=O)O)O)(C(=O)O)O
• Isomeric SMILES: CN1CCC[C@H]1C2=CN=CC=C2.[C@H]([C@@H](C(=O)O)O)(C(=O)O)O.[C@H]([C@@H](C(=O)O)O)(C(=O)O)O
• Inhalation Risk: Evaporation at 20 °C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed.
• Effects of Short Term Exposure: The substance is irritating to the eyes and skin. The substance may cause effects on the central nervous system. This may result in convulsions and respiratory failure. Exposure at high concentrations could cause death. The effects may be delayed. Medical observation is indicated.
• Effects of Long Term Exposure: Animal tests show that this substance possibly causes toxic effects upon human reproduction.
• Uses: nicotinyl acetylchloline receptor agonist, ectoparasiticide cathartic, laxative

Technology Process of Nicotine, tartrate (1:2), (-)-l-

There total 1 articles about Nicotine, tartrate (1:2), (-)-l- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + L-(+)-tartaric acid (87-69-4,133-37-9,147-71-7,147-73-9,526-83-0,138508-61-9) + (+)-nornicotine (7076-23-5,13450-58-3) → (+)-Nicotine bitartrate (65-31-6,1421-32-5,3275-73-8,6550-19-2,50603-04-8,50791-88-3,50915-69-0,51385-03-6,51385-04-7,54661-91-5,129721-88-6,2624-48-8)

Guidance literature:

With sodium cyanoborohydride; Yield given. Multistep reaction; 1.) aq. MeOH, 15 min, 2.) aq. EtOH;

DOI:10.1002/jps.2600770508

Reference yield: 85.0%

1-bromo-butane (109-65-9) + (S)-(-)-nicotine di-L-tartrate (65-31-6,1421-32-5,3275-73-8,6550-19-2,50603-04-8,50791-88-3,50915-69-0,51385-03-6,51385-04-7,54661-91-5,129721-88-6,2624-48-8) → 2Br(1-)*C18H32N2(2+)

Guidance literature:

In methanol; for 4h; Reflux;

DOI:10.1080/00397910903161801

upstream raw materials:

formaldehyd

L-(+)-tartaric acid

(+)-nornicotine

Refernces