Furan-2-carbohydrazide

Base Information

• Chemical Name: Furan-2-carbohydrazide
• CAS No.: 3326-71-4
• Molecular Formula: C5H6N2O2
• Molecular Weight: 126.115
• Hs Code.: 29321900
• European Community (EC) Number: 222-046-2
• NSC Number: 35574,11957
• DSSTox Substance ID: DTXSID10186900
• Nikkaji Number: J1.821J
• Wikidata: Q72479627
• ChEMBL ID: CHEMBL340492
• Mol file: 3326-71-4.mol

Synonyms:2-furoic acid hydrazide

Chemical Property of Furan-2-carbohydrazide

Chemical Property:

• Appearance/Colour: Beige crystals
• Melting Point: 77-79 °C(lit.)
• Refractive Index: 1.535
• Boiling Point: 279°C(lit.)
• PKA: 12.18±0.10(Predicted)
• PSA: 68.26000
• Density: 1.264 g/cm³
• LogP: 0.97430
• Storage Temp.: Store at +15°C to +25°C.
• Solubility.: soluble in Methanol
• XLogP3: -0.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 126.042927438
• Heavy Atom Count: 9
• Complexity: 116

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Furoic acid hydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 22-24/25-36/37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=COC(=C1)C(=O)NN
• Uses: 2-Furoic hydrazide (2-Furoylhydrazine) was used to study the Fourier transform infrared spectra, 1H NMR and 13C NMR spectra. It was also used as a reagent for determination of carbohydrates.

Technology Process of Furan-2-carbohydrazide

There total 16 articles about Furan-2-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-furoic acid methyl ester (611-13-2) → 2-furoic acid hydrazide (3326-71-4)

Guidance literature:

With hydrazine hydrate; In ethanol; for 8h; Reflux;

Reference yield: 80.0%

Ethyl 2-furoate (614-99-3) → 2-furoic acid hydrazide (3326-71-4)

Guidance literature:

With hydrazine hydrate; In ethanol; Reflux; Inert atmosphere;

DOI:10.1080/15533174.2015.1137320

Reference yield: 80.0%

2-furanoic acid (88-14-2) → 2-furoic acid hydrazide (3326-71-4)

Guidance literature:

With hydrazine hydrate; for 0.0472222h; Microwave irradiation;

upstream raw materials:

Ethyl 2-furoate

2-furanoic acid

2-furoic acid methyl ester

N'-[benz-(E)-ylidene]furan-2-ylcarbohydrazide

Downstream raw materials:

furan-2-carboxylic acid N'-(furan-2-ylmethylene)hydrazide

2-acetylfuran-2-furoylhydrazone

5-(furan-2-yl)-1,3,4-oxadiazol-2(3H)-one

[1,4]benzoquinone-(furan-2-carbonylhydrazone)-oxime

Refernces

• 1、 Gavara, Laurent,Legru, Alice,Verdirosa, Federica,Sevaille, Laurent,Nauton, Lionel,Corsica, Giuseppina,Mercuri, Paola Sandra,Sannio, Filomena,Feller, Georges,Coulon, Rémi,De Luca, Filomena,Cerboni, Giulia,Tanfoni, Silvia,Chelini, Giulia,Galleni, Moreno,Docquier, Jean-Denis,Hernandez, Jean-Fran?ois. "4-Alkyl-1,2,4-triazole-3-thione analogues as metallo-β-lactamase inhibitors". supporting information. . Retrieved 2021/06/15.
• 2、 Joly, Nicolas,Bettoni, Léo,Gaillard, Sylvain,Poater, Albert,Renaud, Jean-Luc. "Phosphine-free ruthenium complex-catalyzed synthesis of mono- Or dialkylated acyl hydrazides via the borrowing hydrogen strategy". . p. 6813 - 6825. Retrieved 2021/05/29.