7,8-DIHYDRO-L-BIOPTERIN

Base Information

• Chemical Name: 7,8-DIHYDRO-L-BIOPTERIN
• CAS No.: 6779-87-9
• Molecular Formula: C9H13N5O3
• Molecular Weight: 239.234
• Hs Code.: 2933990090
• Mol file: 6779-87-9.mol

Synonyms:7,8-Dihydrobiopterin;Dihydrobiopterin;L-erythro-7,8-Dihydrobiopterin;L-erythro-Dihydrobiopterin;1,2-Propanediol,1-(2-amino-7,8-dihydro-4-hydroxy-6-pteridinyl)-, L-erythro- (8CI);4(1H)-Pteridinone,2-amino-6-(1,2-dihydroxypropyl)-7,8-dihydro-, [S-(R*,S*)]-;4(1H)-Pteridinone,2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-7,8-dihydro- (9CI);7,8-Dihydro-L-biopterin;

Chemical Property of 7,8-DIHYDRO-L-BIOPTERIN

Chemical Property:

• Vapor Pressure: 7.66E-11mmHg at 25°C
• Melting Point: >300°C dec.
• Refractive Index: 1.821
• Boiling Point: 470.8 °C at 760 mmHg
• PKA: 10.47±0.20(Predicted)
• Flash Point: 238.5 °C
• PSA: 136.62000
• Density: 1.88 g/cm³
• LogP: -1.25340
• Storage Temp.: −20°C
• Solubility.: Aqueous Acid (Slightly, Sonicated), Aqueous Base (Slightly), DMSO (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

7,8-Dihydro-L-biopterin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: BH2 is a precursor of BH4 synthesis. It is a noncompetitive inhibitor of GTP cyclohydrolase I, with a Ki of 14.4 μM.
• Uses: An oxidation producct of tetrahydrobiopterin, a naturally occurring cofactor of the aromatic amino acid hydroxylase and is involved in the synthesis of tyrosine and the neurotransmitters dopamine and serotonin. It is a noncompetitive inhibitor of G The reduced form of Biopterin. An oxidation product of tetrahydrobiopterin, a naturally occurring cofactor of the aromatic amino acid hydroxylase and is involved in the synthesis of tyrosine and the neurotransmitters dopamine and serotonin. It is a noncompetitive inhibitor of GTP cyclohydrolase I, with a Ki of 14.4 μM. BH2 is a precursor of BH4 synthesis. It is a noncompetitive inhibitor of GTP cyclohydrolase I, with a Ki of 14.4 μM.

Technology Process of 7,8-DIHYDRO-L-BIOPTERIN

There total 5 articles about 7,8-DIHYDRO-L-BIOPTERIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-quinonoid (6R)-dihydrobiopterin (79647-29-3) → 7,8-dihydro-L-biopterin (6779-87-9) + (1'R,2'S,6R)-2-amino-6-(1',2'-dihydroxypropyl)-5,6,7,8-tetrahydropterin-4(3H)-one-dihydrochloride (62989-33-7) + biopterin (22150-76-1)

Guidance literature:

pH=7;

DOI:10.1016/S0040-4039(00)84047-2

Reference yield:

biopterin (22150-76-1) → (6R)-5,6,7,8-tetrahydrobiopterin dihydrochloride + 7,8-dihydro-L-biopterin (6779-87-9)

Guidance literature:

biopterin; With hydrogen; triethylamine; platinum; In water; at 25 ℃; for 23h; under 26252.6 Torr; pH=11.2;

With hydrogenchloride; In water; at 25 ℃; pH=< 1.0; Product distribution / selectivity;

Reference yield:

6,7-dihydrobiopterin → 7,8-dihydro-L-biopterin (6779-87-9)

Guidance literature:

Multi-step reaction with 2 steps

1: dihydropteridine reductase from Escherichia coli Bl-21; NADH / aq. buffer / 1 h / 25 °C / pH 7.4 / Enzymatic reaction

2: oxygen / 60 h / 37 °C

With oxygen; dihydropteridine reductase from Escherichia coli Bl-21; NADH; In aq. buffer;

DOI:10.1039/d0cy01958e

upstream raw materials:

p-quinonoid (6R)-dihydrobiopterin

biopterin

Downstream raw materials:

7,8-dihydroxanthopterin

6-formyl-7,8-dihydropterin

biopterin

6-formylpterin

Refernces

• 1、 -. "METHOD OF SYNTHESIZING TETRAHYDROBIOPTERIN". Page/Page column 11-12. . Retrieved 2009/08/16.