Technology Process of 11-deoxy-11-(carboxybenzylamino)-6-O-methylerythromycin A 11,12-(cyclic ester)
There total 6 articles about 11-deoxy-11-(carboxybenzylamino)-6-O-methylerythromycin A 11,12-(cyclic ester) which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
methanol;
for 2h;
under 3040 Torr;
Yield given;
Ambient temperature;
DOI:10.1021/jo00245a038
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 73 percent / triethylamine / CH2Cl2 / 5.5 h
2: 87 percent / (dimethylamino)pyridine (DMAP) / CH2Cl2 / 1.) -40 deg C, 1 h, 2.) -20 deg C, 72 h
3: 1.) sodium bis(trimethylsilyl)amide / 1.) THF, -40 deg C, 2.5 h, 2.) DMF, 18 h
4: 84 percent / H2O; acetonitrile / 4.5 h
5: MeOH / 96 h / Ambient temperature
6: H2 / Pd/C / methanol / 2 h / 3040 Torr / Ambient temperature
With
methanol; dmap; hydrogen; sodium hexamethyldisilazane; triethylamine;
palladium on activated charcoal;
In
methanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jo00245a038
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 87 percent / (dimethylamino)pyridine (DMAP) / CH2Cl2 / 1.) -40 deg C, 1 h, 2.) -20 deg C, 72 h
2: 1.) sodium bis(trimethylsilyl)amide / 1.) THF, -40 deg C, 2.5 h, 2.) DMF, 18 h
3: 84 percent / H2O; acetonitrile / 4.5 h
4: MeOH / 96 h / Ambient temperature
5: H2 / Pd/C / methanol / 2 h / 3040 Torr / Ambient temperature
With
methanol; dmap; hydrogen; sodium hexamethyldisilazane;
palladium on activated charcoal;
In
methanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jo00245a038