2-Fluoroethanol

Base Information

• Chemical Name: 2-Fluoroethanol
• CAS No.: 371-62-0
• Molecular Formula: C2H5FO
• Molecular Weight: 64.0595
• Hs Code.: 29055900
• European Community (EC) Number: 206-740-2
• NSC Number: 158283
• UN Number: 2929,2642
• UNII: 4M427A5HML
• DSSTox Substance ID: DTXSID0059902
• Nikkaji Number: J5.709F
• Wikipedia: 2-Fluoroethanol
• Wikidata: Q209389
• ChEMBL ID: CHEMBL115586
• Mol file: 371-62-0.mol

Synonyms:2-fluoroethanol;2-fluoroethanol, sodium salt;fluoroethanol

Chemical Property of 2-Fluoroethanol

Chemical Property:

• Appearance/Colour: Colorless Liquid
• Vapor Pressure: 16 mm Hg ( 20 °C)
• Melting Point: -26.5 °C(lit.)
• Refractive Index: n20/D 1.365(lit.)
• Boiling Point: 103.5 °C at 760 mmHg
• PKA: 13.92±0.10(Predicted)
• Flash Point: 31.1 °C
• PSA: 20.23000
• Density: 0.993 g/cm³
• LogP: -0.05180
• Sensitive.: Air Sensitive
• Solubility.: Fully miscible.
• XLogP3: -0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 64.032442941
• Heavy Atom Count: 4
• Complexity: 10
• Transport DOT Label: Poison Flammable Liquid

Purity/Quality:

99% ^*data from raw suppliers

2-Fluoroethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F; T+
• Hazard Codes: T+,T,F
• Statements: 10-26/27/28-36/37/38
• Safety Statements: 36/37/39-45-23-16

MSDS Files:

Useful:

• Chemical Classes: Pesticides -> Other Insecticides,Toxic Gases & Vapors -> Other Toxic Gases & Vapors
• Canonical SMILES: C(CF)O
• Uses: 2-Fluoroethanol, is used in the microwave spectra of two isotopic species of 2-fluoroethanol have been investigated. The Gg conformer of 2-fluoroethanol is isolated in low-temperature noble gas matrices. Single-photon IR photolysis of 2-fluoroethanol in solid argon has been investigated.

Technology Process of 2-Fluoroethanol

There total 31 articles about 2-Fluoroethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-fluoroethyl fluorosulfite (108198-35-2) → 2-fluoroethanol (371-62-0)

Guidance literature:

With potassium hydroxide; In water; for 2h;

Reference yield: 70.0%

2-bromoethanol (540-51-2) → 2-fluoroethanol (371-62-0)

Guidance literature:

With potassium fluoride; cetyltributylphosphonium bromide; at 60 ℃; for 0.5h;

DOI:10.1016/S0022-1139(99)00121-9

Reference yield: 20.0%

N3-cyclohexyl-N1-(2-fluoroethyl)-N1-nitrosothiourea (79645-05-9) → N-cyclohexyl-4,5-dihydro-1,3-thiazol-2-amine (56242-66-1) + 2-fluoroethanol (371-62-0) + 2-(cyclohexylimino)-3-nitrosothiazolidine (87191-81-9) + isothiocyanatocyclohexane (1122-82-3)

Guidance literature:

With potassium phosphate buffer; at 37 ℃; for 12h; Product distribution; Mechanism; decomposition by var. pH;

DOI:10.1021/jo00170a006

upstream raw materials:

oxirane

methyl fluoroacetate

Tetrakis-(2-hydroxy-aethyl)-ammonium-fluorid

2-chloro-ethanol

Downstream raw materials:

2-(2-(2-fluoroethoxy)ethoxy)ethanol

2-(2-fluoroethoxy)ethanol

2-fluoroethyl chloroformate

(2-methyl-4-o-tolylazo-phenyl)-carbamic acid-(2-fluoro-ethyl ester)

Refernces

• 1、 Tsukimori, Naoko,Nanbu, Noritoshi,Takehara, Masahiro,Ue, Makoto,Sasaki, Yukio. "Electrolytic properties of ethyl fluoroethyl carbonate and its application to lithium battery". . p. 368 - 369. Retrieved 2008.
• 2、 Wojcik-Pastuszka,Golonka,Ratajczak. "Spectrokinetic study of the reaction system of 2NO2?N 2O4 with some fluorinated derivatives of ethanol and propanols between 293-358 K in the gas phase". . p. 1559 - 1574. Retrieved 2008/02/04.