4-Tolylhydrazine Monohydrochloride

Base Information

• Chemical Name: 4-Tolylhydrazine Monohydrochloride
• CAS No.: 637-60-5
• Molecular Formula: C7H11ClN2
• Molecular Weight: 158.631
• Hs Code.: 29280090
• Mol file: 637-60-5.mol

Synonyms:(4-methylanilino)azanium;chloride;4-Tolylhydrazine Monohydrochloride;SCHEMBL15994327;AKOS023093333

Chemical Property of 4-Tolylhydrazine Monohydrochloride

Chemical Property:

• Appearance/Colour: off-white to beige-brownish flaky powder
• Melting Point: > 200 °C (dec.)(lit.)
• Refractive Index: 1.6230 (estimate)
• Boiling Point: 242.8 °C at 760 mmHg
• Flash Point: 115.3 °C
• PSA: 38.05000
• Density: 1.18 g/cm³
• LogP: 2.85590
• Storage Temp.: Store below +30°C.
• Solubility.: DMSO, Methanol
• Water Solubility.: soluble
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 158.0610761
• Heavy Atom Count: 10
• Complexity: 75

Purity/Quality:

99% ^*data from raw suppliers

4-TolylhydrazineMonohydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi
• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38-40
• Safety Statements: 26-36-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)N[NH3+].[Cl-]
• Uses: 4-Tolylhydrazine Monohydrochloride has shown tumorigenic potential through studies. In addition, due to its hydrazine moiety, it has anti-cancer potential and is a compound from which derivatives are made in the search of novel anticancer drugs. 4-Tolylhydrazine Monohydrochloride has shown tumorigenic potential through studies. In addition, due to its hydrazine moiety, it has anti-cancer potential and is a compound from which derivatives are made in the search of novel anticancer drugs.

Technology Process of 4-Tolylhydrazine Monohydrochloride

There total 11 articles about 4-Tolylhydrazine Monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(4-methylphenyl) benzophenone hydrazone (40594-88-5) → p-tolylhydrazine hydrochloride (637-60-5,35467-65-3)

Guidance literature:

With hydrogenchloride; In ethanol; water; at 20 ℃; for 24h; Inert atmosphere; Industrial scale;

DOI:10.1021/op049832y

Reference yield: 90.0%

p-toluidine (106-49-0,12221-03-3) → p-tolylhydrazine hydrochloride (637-60-5,35467-65-3)

Guidance literature:

p-toluidine; With hydrogenchloride; sodium nitrite; In water; for 1h;

With sodium sulfite; In water; at 80 ℃; for 0.1h;

With hydrogenchloride; In water; at 20 - 95 ℃;

Reference yield: 85.0%

4-tolyl iodide (624-31-7) → p-tolylhydrazine hydrochloride (637-60-5,35467-65-3)

Guidance literature:

4-tolyl iodide; With potassium phosphate; copper(l) iodide; N,N′-bis(2,6-dimethylphenyl)oxalamide; cetyltrimethylammonim bromide; In water; at 80 ℃; for 0.25h; Schlenk technique; Inert atmosphere; Sealed tube;

With hydrazine hydrate; In water; at 80 ℃; Inert atmosphere; Schlenk technique; Sealed tube;

With hydrogenchloride; In water; pH=3 - 4; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1002/cjoc.201800326

upstream raw materials:

ethanol

4-chloro-3-(4-tolyl)sydnone

3-(4-methylphenyl)sydnone

p-toluidine

Downstream raw materials:

7-Methyl-4H-2,3-dihydrothieno<3,2-b>indol

N-(2,3,4,5-Tetraphenyl-cyclopenta-2,4-dienylidene)-N'-p-tolyl-hydrazine

N-[3,3-Dichloro-prop-2-en-(E)-ylidene]-N'-p-tolyl-hydrazine

biphenyl

Refernces

• 1、 Lombardi, Lorenzo,Bellini, Daniele,Bottoni, Andrea,Calvaresi, Matteo,Monari, Magda,Kovtun, Alessandro,Palermo, Vincenzo,Melucci, Manuela,Bandini, Marco. "Allylic and Allenylic Dearomatization of Indoles Promoted by Graphene Oxide by Covalent Grafting Activation Mode". supporting information. p. 10427 - 10432. Retrieved 2020/07/24.
• 2、 Bi, Fangchao,Song, Di,Qin, Yinhui,Liu, Xingbang,Teng, Yuetai,Zhang, Na,Zhang, Panpan,Zhang, Nan,Ma, Shutao. "Discovery of 1,3,4-oxadiazol-2-one-containing benzamide derivatives targeting FtsZ as highly potent agents of killing a variety of MDR bacteria strains". . p. 3179 - 3193. Retrieved 2019/06/17.