Technology Process of 3-(2,5-Difluorobenzenesulfonylamino)-2-fluorobenzoic acid methyl ester
There total 8 articles about 3-(2,5-Difluorobenzenesulfonylamino)-2-fluorobenzoic acid methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
pyridine;
at 0 - 20 ℃;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: hydrogen / 5%-palladium/activated carbon / methanol / 45 h / 20 °C
2: sulfuric acid / 44 h / Reflux
3: pyridine / dichloromethane / 20 °C
With
pyridine; sulfuric acid; hydrogen;
5%-palladium/activated carbon;
In
methanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: caesium carbonate / tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere
2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
3: pyridine / dmap / dichloromethane / 0 - 20 °C
With
pyridine; caesium carbonate; trifluoroacetic acid;
dmap; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
dichloromethane; toluene;