Technology Process of 1-(4-(tert-butyl)benzyl)-3-(3-(4'-(3-hydroxyoxetan-3-yl)-[1,1'-biphenyl]-4-yl)propyl)-1H-1,2,4-triazol-5(4H)-one
There total 7 articles about 1-(4-(tert-butyl)benzyl)-3-(3-(4'-(3-hydroxyoxetan-3-yl)-[1,1'-biphenyl]-4-yl)propyl)-1H-1,2,4-triazol-5(4H)-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); water;
In
1,2-dimethoxyethane;
at 110 ℃;
for 18h;
Inert atmosphere;
Sealed tube;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: camphor-10-sulfonic acid / ethyl acetate / 16 h / 80 °C
2: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); water / 1,2-dimethoxyethane / 18 h / 110 °C / Inert atmosphere; Sealed tube
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); camphor-10-sulfonic acid; water;
In
1,2-dimethoxyethane; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C
2: camphor-10-sulfonic acid / ethyl acetate / 16 h / 80 °C
3: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); water / 1,2-dimethoxyethane / 18 h / 110 °C / Inert atmosphere; Sealed tube
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); camphor-10-sulfonic acid; water; N-ethyl-N,N-diisopropylamine; HATU;
In
1,2-dimethoxyethane; ethyl acetate; N,N-dimethyl-formamide;