Dihydralazine

Base Information

• Chemical Name: Dihydralazine
• CAS No.: 484-23-1
• Molecular Formula: C8H10 N6
• Molecular Weight: 190.208
• Hs Code.: 2933990090
• European Community (EC) Number: 207-605-0
• NSC Number: 526654
• UNII: PCU411F5L6
• DSSTox Substance ID: DTXSID0022935
• Nikkaji Number: J5.994C
• Wikipedia: Dihydralazine
• Wikidata: Q408370
• NCI Thesaurus Code: C97307
• Metabolomics Workbench ID: 153831
• ChEMBL ID: CHEMBL35505
• Mol file: 484-23-1.mol

Synonyms:Depressan;Dihydralazine;Dihydralazine Sulfate;Dihydrallazine;Dihydrazinophthalazin;Sulfate, Dihydralazine

Chemical Property of Dihydralazine

Chemical Property:

• Vapor Pressure: 1.09E-16mmHg at 25°C
• Melting Point: 180ºC
• Refractive Index: 1.899
• Boiling Point: 648.3 °C at 760 mmHg
• PKA: 3?+-.0.20(Predicted)
• Flash Point: 345.9 °C
• PSA: 108.34000
• Density: 1.543 g/cm³
• LogP: 0.44540
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 190.09669434
• Heavy Atom Count: 14
• Complexity: 167

Purity/Quality:

98% ^*data from raw suppliers

1,4-Dihydraziny-phthalazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(=NN=C2NN)NN
• Recent ClinicalTrials: Effect of Antifibrotic Therapy on Regression of Myocardial Fibrosis After Transcatheter Aortic Valve Implantation (TAVI) in Aortic Stenosis Patients With High Fibrotic Burden
• Uses: Ophthazin is an antihypertensive agent of the hydrazine class used during pregnancies in dialysis patients with familial mediterranean fever and cystinosis under hemodialysis.
• Therapeutic Function: Antihypertensive

Technology Process of Dihydralazine

There total 14 articles about Dihydralazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phthalonitrile (91-15-6) → 1,4-bis(hydrazino)phthalazine (484-23-1)

Guidance literature:

With hydrazine hydrate;

DOI:10.1021/jo01091a010

Reference yield:

1-Chloro-4-methoxyphthalazine (19064-71-2) → 1,4-bis(hydrazino)phthalazine (484-23-1)

Guidance literature:

With hydrazine hydrate;

DOI:10.1002/hlca.19510340122

Reference yield:

1,4-dichlorophthalazine (4752-10-7) → 1,4-bis(hydrazino)phthalazine (484-23-1)

Guidance literature:

With hydrazine hydrate;

upstream raw materials:

2,3-dihydro-phthalazine-1,4-dithione

1-Chloro-4-methoxyphthalazine

1-chloro-4-ethoxyphthalazine

1-chloro-4-hydrazinophthalazine

Downstream raw materials:

1,4-bis-benzylidenehydrazino-phthalazine

6-(3,5-dimethylpyrazol-1-yl)-3-methyl-[1,2,4]triazolo[3,4-a]phthalazine

1,4-Bis(3,5-dimethylpyrazol-1-yl)phthalazin

1,4-bis(3,5-diphenylpyrazol-1-yl)phthalazine

Refernces

• 1、 Shaikh,Johnson,Grollman. "Streptonigrin. 1. Structure-activity relationships among simple bicyclic analogues. Rate dependence of DNA degradation on quinone reduction potential". . p. 1329 - 1340. Retrieved 2007/10/02.