Technology Process of propan-2-yl (5Z)-7-[(1R,2R,3R,5S)-3,5-bis(acetyloxy)-2-[(1E)-3,3-difluoro-4-phenoxybut-1-en-1-yl]cyclopentyl]hept-5-enoate
There total 7 articles about propan-2-yl (5Z)-7-[(1R,2R,3R,5S)-3,5-bis(acetyloxy)-2-[(1E)-3,3-difluoro-4-phenoxybut-1-en-1-yl]cyclopentyl]hept-5-enoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
(bis-(2-methoxyethyl)amino)sulfur trufluoride;
In
dichloromethane;
at 20 - 30 ℃;
for 72h;
Reagent/catalyst;
Solvent;
Temperature;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; 1,4-dioxane / 11 h / 25 - 40 °C
2: triethylamine; dmap / dichloromethane / 1 h / 25 °C
3: Deoxo-Fluor / tetrahydrofuran; dichloromethane / 26 h / 0 - 40 °C
With
dmap; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyllithium; tetrabutylammomium bromide / dichloromethane / 1 h / 20 - 30 °C
1.2: 15 h / 20 °C
2.1: toluene-4-sulfonic acid / methanol / 15 h / 0 °C
3.1: triethylamine; dmap / dichloromethane / 15 h / 20 °C / Inert atmosphere
4.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 72 h / 20 - 30 °C
With
dmap; n-butyllithium; tetrabutylammomium bromide; toluene-4-sulfonic acid; triethylamine; (bis-(2-methoxyethyl)amino)sulfur trufluoride;
In
methanol; dichloromethane;
1.1: |Horner-Wadsworth-Emmons Olefination / 1.2: |Horner-Wadsworth-Emmons Olefination;