Antazoline

Base Information

• Chemical Name: Antazoline
• CAS No.: 91-75-8
• Molecular Formula: C17H19N3
• Molecular Weight: 265.358
• European Community (EC) Number: 202-094-0
• UNII: DHA8014SS1
• DSSTox Substance ID: DTXSID3022613
• Nikkaji Number: J4.345A
• Wikipedia: Antazoline
• Wikidata: Q771975
• NCI Thesaurus Code: C61638
• Pharos Ligand ID: KKCY9J5G3ZK5
• Metabolomics Workbench ID: 43716
• ChEMBL ID: CHEMBL1305
• Mol file: 91-75-8.mol

Synonyms:Analergine;Antasten;Antazoline;Antazoline Hydrochloride;Antazoline Phosphate;Antazoline Phosphate (1:1);Antistine;Arithmin;Hydrochloride, Antazoline;Imidamine;Phenazoline;Phosphate, Antazoline

Chemical Property of Antazoline

Chemical Property:

• Appearance/Colour: Crystals. Odorless.
• Melting Point: 159oC
• Refractive Index: 1.6080 (estimate)
• Boiling Point: 475.5 °C at 760 mmHg
• PKA: pKa 6.65(H2O t = 25 I = 0.05) (Uncertain)
• Flash Point: 241.4 °C
• PSA: 27.63000
• Density: 1.1 g/cm³
• LogP: 2.45930
• Water Solubility.: 663.4mg/L(30 oC)
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 265.157897619
• Heavy Atom Count: 20
• Complexity: 314

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CN=C(N1)CN(CC2=CC=CC=C2)C3=CC=CC=C3
• Recent ClinicalTrials: Antazoline in Comparison to Propafenone in Pharmacological Cardioversion of Atrial Fibrillation.
• Uses: Antihistaminic.
• Therapeutic Function: Antihistaminic

Technology Process of Antazoline

There total 9 articles about Antazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2-[benzyl(phenyl)amino]acetonitrile (36271-19-9) + ethylenediamine (107-15-3,85404-18-8) → antazoline (91-75-8)

Guidance literature:

With thioacetamide; for 3h; Heating;

DOI:10.1002/jhet.5570430221

Reference yield:

antazoline phosphate (154-68-7) → antazoline (91-75-8)

Guidance literature:

With sodium hydroxide; In water;

DOI:10.1080/15421406.2014.905041

Reference yield:

N-(N-benzyl-N-phenyl-glycyl)-glycine nitrile → antazoline (91-75-8)

Guidance literature:

With ammonia; nickel; isopropyl alcohol; at 125 ℃; under 95616 Torr; Hydrogenation_.und anschliessenden Erhitzen unter verminderten Druck auf 150grad;

upstream raw materials:

Phenamazolin

benzyl chloride

N-Benzylaniline

2-(chloromethyl)-2-imidazoline hydrochloride

Downstream raw materials:

N-<(N-benzylanilino)acetyl>ethylenediamine

Refernces

• 1、 Dash,Kudav,Parihar. "A new and convenient synthesis of antazoline derivatives". . p. 401 - 404. Retrieved 2007/10/03.