25-Bromo-2,5,8,11,14,17,20,23-octaoxapentacosane

Base Information

• Chemical Name: 25-Bromo-2,5,8,11,14,17,20,23-octaoxapentacosane
• CAS No.: 1056881-04-9
• Molecular Formula: C₁₇H₃₅BrO₈
• Molecular Weight: 447.364
• Mol file: 1056881-04-9.mol

Synonyms:octaethylene glycol monomethyl ether bromide

Chemical Property of 25-Bromo-2,5,8,11,14,17,20,23-octaoxapentacosane

Chemical Property:

• Boiling Point: 462.5±40.0 °C(Predicted)
• Density: 1.198±0.06 g/cm3(Predicted)
• Solubility.: Soluble in Water, DMSO, DMF, DCM

Purity/Quality:

99.3% ^*data from raw suppliers

25-Bromo-2,5,8,11,14,17,20,23-octaoxapentacosane min.95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: m-PEG8-bromide is a PEG linker containing a bromide group. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media.

Technology Process of 25-Bromo-2,5,8,11,14,17,20,23-octaoxapentacosane

There total 1 articles about 25-Bromo-2,5,8,11,14,17,20,23-octaoxapentacosane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2,5,8,11,14,17,20,23-octaoxapentacosan-25-yl 4-methylbenzenesulfonate (82217-01-4) → octaethylene glycol monomethyl ether bromide (1056881-04-9)

Guidance literature:

With lithium bromide; In acetone; at 80 ℃; for 24h;

Reference yield: 46.0%

octaethylene glycol monomethyl ether bromide (1056881-04-9) + (rac)-mexiletine hydrochloride (5370-01-4) → N-mPEG8-Mexiletine (1147861-67-3)

Guidance literature:

With potassium carbonate; In water; at 120 ℃; for 0.5h; Microwave irradiation;

Reference yield:

octaethylene glycol monomethyl ether bromide (1056881-04-9) + nalbuphine (20594-83-6) → 6-O-mPEG8Nalbuphine (1056880-94-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; acetone; toluene; at 100 ℃; for 3.5h; CEM microwave;

upstream raw materials:

2,5,8,11,14,17,20,23-octaoxapentacosan-25-yl 4-methylbenzenesulfonate

Downstream raw materials:

6-O-mPEG₈Nalbuphine

N-mPEG₈-Mexiletine

Refernces