Multi-step reaction with 3 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere
1.2: 16 h / 20 °C
2.1: dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; caesium carbonate; [(2-di-cyclohexylphosphino-3,6-dimethoxy-2,4,6-triisopropyl-1,1-biphenyl)-2-(2-amino-1,1-biphenyl)]palladium(II) methanesulfonate / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere; Sealed tube
3.1: palladium on activated charcoal; hydrogen / methanol; ethyl acetate / 16 h / 20 °C / Inert atmosphere
With
dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; palladium on activated charcoal; [(2-di-cyclohexylphosphino-3,6-dimethoxy-2,4,6-triisopropyl-1,1-biphenyl)-2-(2-amino-1,1-biphenyl)]palladium(II) methanesulfonate; hydrogen; caesium carbonate; lithium hexamethyldisilazane;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethyl acetate;