17α-methyl-17β-(3-phenyl-propionyloxy)-(5α)-androstano[2,3-c][1,2,5]oxadiazole

Base Information

• Chemical Name: 17α-methyl-17β-(3-phenyl-propionyloxy)-(5α)-androstano[2,3-c][1,2,5]oxadiazole
• CAS No.: 3662-93-9
• Molecular Formula: C₂₉H₃₈N₂O₃
• Molecular Weight: 462.632
• Mol file: 3662-93-9.mol

Synonyms:17α-methyl-17β-(3-phenyl-propionyloxy)-(5α)-androstano[2,3-c][1,2,5]oxadiazole

Chemical Property of 17α-methyl-17β-(3-phenyl-propionyloxy)-(5α)-androstano[2,3-c][1,2,5]oxadiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 17α-methyl-17β-(3-phenyl-propionyloxy)-(5α)-androstano[2,3-c][1,2,5]oxadiazole

There total 5 articles about 17α-methyl-17β-(3-phenyl-propionyloxy)-(5α)-androstano[2,3-c][1,2,5]oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-phenylpropionic anhydride (15781-96-1) + Frazalon (1239-29-8) → 17α-methyl-17β-(3-phenyl-propionyloxy)-(5α)-androstano[2,3-c][1,2,5]oxadiazole (3662-93-9)

Guidance literature:

Multistep reaction; (i) EtMgBr, Et₂O, (ii) /BRN= 3100932/;

DOI:10.1248/cpb.13.1445

Reference yield:

mestanolone (521-11-9,7241-35-2) → 17α-methyl-17β-(3-phenyl-propionyloxy)-(5α)-androstano[2,3-c][1,2,5]oxadiazole (3662-93-9)

Guidance literature:

Multi-step reaction with 4 steps

1: O₂, KOtBu / 2-methyl-propan-2-ol

2: aq. NH₂OH*HCl

3: KOH / ethane-1,2-diol / 180 - 190 °C

4: (i) EtMgBr, Et₂O, (ii) /BRN= 3100932/

With potassium hydroxide; hydroxylamine hydrochloride; potassium tert-butylate; oxygen; In ethylene glycol; tert-butyl alcohol;

DOI:10.1248/cpb.13.1445

Reference yield:

17β-hydroxy-17α-methyl-(5α)-androstane-2,3-dione dioxime (3137-81-3) → 17α-methyl-17β-(3-phenyl-propionyloxy)-(5α)-androstano[2,3-c][1,2,5]oxadiazole (3662-93-9)

Guidance literature:

Multi-step reaction with 2 steps

1: KOH / ethane-1,2-diol / 180 - 190 °C

2: (i) EtMgBr, Et₂O, (ii) /BRN= 3100932/

With potassium hydroxide; In ethylene glycol;

DOI:10.1248/cpb.13.1445

upstream raw materials:

3-phenylpropionic anhydride

Frazalon

mestanolone

17β-hydroxy-17α-methyl-(5α)-androstane-2,3-dione dioxime

Refernces