Butyric acid hydrazide

Base Information

• Chemical Name: Butyric acid hydrazide
• CAS No.: 3538-65-6
• Molecular Formula: C4H10N2O
• Molecular Weight: 102.136
• Hs Code.: 2928000090
• European Community (EC) Number: 222-579-0
• NSC Number: 41957,24021
• DSSTox Substance ID: DTXSID70188869
• Nikkaji Number: J216.183D
• Wikidata: Q83060728
• Pharos Ligand ID: YBG4YHVDVLCY
• ChEMBL ID: CHEMBL4458461
• Mol file: 3538-65-6.mol

Synonyms:Butyric acid hydrazide;Butyrohydrazide;3538-65-6;butanehydrazide;Butanoic acid, hydrazide;Butanohydrazide;Butyrylhydrazine;butanoic acid hydrazide;n-Butyric acid hydrazide;EINECS 222-579-0;MFCD00025135;butyric hydrazide;Butanohydrazide #;Butyricacidhydrazide;N-butanoyl-hydrazine;SCHEMBL924945;Mr-I-33;CHEMBL4458461;SCHEMBL11029887;DTXSID70188869;BDBM233138;NSC24021;NSC41957;NSC 24021;NSC 41957;NSC-24021;NSC-41957;STK397805;AKOS000155701;DS-2151;SB85901;SY060413;BB 0240969;CS-0152447;FT-0623346;EN300-192673;O11707;F3191-0132

Chemical Property of Butyric acid hydrazide

Chemical Property:

• Vapor Pressure: 0.0224mmHg at 25°C
• Melting Point: 46-49°C
• Refractive Index: 1.445
• Boiling Point: 249.8 °C at 760 mmHg
• PKA: 13.53±0.18(Predicted)
• Flash Point: 104.9 °C
• PSA: 55.12000
• Density: 0.98 g/cm³
• LogP: 0.86760
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: -0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 102.079312947
• Heavy Atom Count: 7
• Complexity: 62.7

Purity/Quality:

99%, ^*data from raw suppliers

Butyrohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 20/21/22
• Safety Statements: 23-26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCC(=O)NN

Technology Process of Butyric acid hydrazide

There total 13 articles about Butyric acid hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

butanoic acid methyl ester (623-42-7) → butyric acid hydrazide (3538-65-6)

Guidance literature:

With hydrazine hydrate; for 5h; Heating;

DOI:10.1016/S0968-0896(02)00611-9

Reference yield: 89.0%

N-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)butyramide (19162-44-8) → 2-amino-1H-benzo[de]isoquinoline-1,3(2H)-dione (5690-46-0) + butyric acid hydrazide (3538-65-6)

Guidance literature:

With hydrazine hydrate; In ethanol; for 3h; Reflux;

DOI:10.1002/chem.202102593

Reference yield: 84.0%

butyric acid (107-92-6) → butyric acid hydrazide (3538-65-6)

Guidance literature:

With hydrazine hydrate; for 0.025h; Microwave irradiation;

upstream raw materials:

butanoic acid ethyl ester

(E)-2-butenehydrazide

butanoic acid methyl ester

hydrazine

Downstream raw materials:

butyric acid benzylidenehydrazide

butanamide

3,5-di(n-propyl)-4-amino-1,2,4-triazole

N-cyclohexylbutyrylamide

Refernces

• 1、 Manoj Kumar, Mesram,Venkataramana, Parikibanda,Yadagiri Swamy, Parikibanda,Chityala, Yadaiah. "N-Amino-1,8-Naphthalimide is a Regenerated Protecting Group for Selective Synthesis of Mono-N-Substituted Hydrazines and Hydrazides". supporting information. p. 17713 - 17721. Retrieved 2021/11/10.
• 2、 -. "PRECURSOR COMPOUNDS OF ESTER COMPOUNDS". Paragraph 00127-00128. . Retrieved 2020/12/30.