Technology Process of N-[3-(2-(1,1-dimethylethyl)-5-{2-[2-(methylsulfonyl)ethyl]-4-pyrimidinyl}-1,3-thiazol-4-yl)-2-fluorophenyl]-2,6-difluorobenzenesulfonamide
There total 12 articles about N-[3-(2-(1,1-dimethylethyl)-5-{2-[2-(methylsulfonyl)ethyl]-4-pyrimidinyl}-1,3-thiazol-4-yl)-2-fluorophenyl]-2,6-difluorobenzenesulfonamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
acetic acid;
In
ethanol;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: caesium carbonate / tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere
2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
3.1: pyridine / dichloromethane / 20 °C
4.1: lithium hexamethyldisilazane / tetrahydrofuran / 20 °C / Cooling with ice-water
5.1: N-Bromosuccinimide / N,N-dimethyl acetamide / 0.25 h / 20 °C
5.2: 20 - 80 °C
6.1: triethylamine / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / propan-1-ol / 100 °C
7.1: acetic acid / ethanol / 20 °C
With
pyridine; N-Bromosuccinimide; caesium carbonate; acetic acid; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane;
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
tetrahydrofuran; propan-1-ol; ethanol; dichloromethane; N,N-dimethyl acetamide; toluene;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: hydrazine hydrate / nickel / tetrahydrofuran; methanol; water / 70 °C
2.1: pyridine / dichloromethane / 20 °C
3.1: lithium hexamethyldisilazane / tetrahydrofuran / 20 °C / Cooling with ice-water
4.1: N-Bromosuccinimide / N,N-dimethyl acetamide / 0.25 h / 20 °C
4.2: 20 - 80 °C
5.1: triethylamine / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / propan-1-ol / 100 °C
6.1: acetic acid / ethanol / 20 °C
With
pyridine; N-Bromosuccinimide; hydrazine hydrate; acetic acid; triethylamine; lithium hexamethyldisilazane;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; nickel;
In
tetrahydrofuran; methanol; propan-1-ol; ethanol; dichloromethane; N,N-dimethyl acetamide; water;