Dihydro-8-(p-bromobenzyl)berberine

Base Information

• Chemical Name: Dihydro-8-(p-bromobenzyl)berberine
• CAS No.: 109855-57-4
• Molecular Formula: C₂₇H₂₄BrNO₄
• Molecular Weight: 506.396
• Mol file: 109855-57-4.mol

Synonyms:Dihydro-8-(p-bromobenzyl)berberine

Chemical Property of Dihydro-8-(p-bromobenzyl)berberine

Chemical Property:

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Technology Process of Dihydro-8-(p-bromobenzyl)berberine

There total 1 articles about Dihydro-8-(p-bromobenzyl)berberine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

berberine chloride (633-65-8) + 1-bromomethyl-4-bromobenzene (589-15-1) → Dihydro-8-(p-bromobenzyl)berberine (109855-57-4)

Guidance literature:

With magnesium; Yield given. Multistep reaction; 1) Ethyl ether, reflux, 2 h, 2) room temperature, stirred overnight;

DOI:10.1002/jhet.5570230440

Reference yield: 92.0%

Dihydro-8-(p-bromobenzyl)berberine (109855-57-4) → Tetrahydro-8-(p-bromobenzyl)berberine (109855-58-5)

Guidance literature:

With sodium tetrahydroborate; In methanol; for 2h; Ambient temperature;

DOI:10.1002/jhet.5570230440

upstream raw materials:

berberine chloride

1-bromomethyl-4-bromobenzene

Downstream raw materials:

Tetrahydro-8-(p-bromobenzyl)berberine

Refernces