N,N′-1,4-phenylenebis(oxamic acid)

Base Information

• Chemical Name: N,N′-1,4-phenylenebis(oxamic acid)
• CAS No.: 53882-05-6
• Molecular Formula: C₁₀H₈N₂O₆
• Molecular Weight: 252.183
• Mol file: 53882-05-6.mol

Synonyms:N,N′-1,4-phenylenebis(oxamic acid)

Chemical Property of N,N′-1,4-phenylenebis(oxamic acid)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N′-1,4-phenylenebis(oxamic acid)

There total 5 articles about N,N′-1,4-phenylenebis(oxamic acid) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.5%

diethyl 1,3-phenylenebis(oxamate) (24200-23-5) → N,N′-1,4-phenylenebis(oxamic acid) (53882-05-6)

Guidance literature:

With water; sodium hydroxide; for 0.5h;

DOI:10.1021/cg300877r

Reference yield: 91.0%

C10H6N2O6(2-)*2K(1+) → N,N′-1,4-phenylenebis(oxamic acid) (53882-05-6)

Guidance literature:

With hydrogenchloride; In water; pH=2;

DOI:10.1021/acs.cgd.6b00613

Reference yield:

m-phenylenediamine (108-45-2,64554-26-3,76583-20-5) → N,N′-1,4-phenylenebis(oxamic acid) (53882-05-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / dimethylformamide

2: aq. NaOH / CH₂Cl₂

With sodium hydroxide; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00207a016

upstream raw materials:

oxalic acid diethyl ester

m-acetamide aniline

diethyl 1,3-phenylenebis(oxamate)

m-phenylenediamine

Refernces

• 1、 Oliveira, Willian X. C.,Pinheiro, Carlos B.,Da Costa, Marinez M.,Fontes, Ana P. S.,Nunes, Wallace C.,Lloret, Francesc,Julve, Miguel,Pereira, Cynthia L. M.. "Crystal Engineering Applied to Modulate the Structure and Magnetic Properties of Oxamate Complexes Containing the [Cu(bpca)]+ Cation". . p. 4094 - 4107. Retrieved 2016.
• 2、 -. "Cytoprotective use of oxamate derivatives". . . Retrieved 2008/06/13.