2-((2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)ethyl)malonic acid diethyl ester

Base Information

• Chemical Name: 2-((2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)ethyl)malonic acid diethyl ester
• CAS No.: 1373492-23-9
• Molecular Formula: C₂₂H₂₆ClNO₄S
• Molecular Weight: 435.972
• Mol file: 1373492-23-9.mol

Synonyms:2-((2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)ethyl)malonic acid diethyl ester

Chemical Property of 2-((2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)ethyl)malonic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-((2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)ethyl)malonic acid diethyl ester

There total 3 articles about 2-((2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)ethyl)malonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(2-chloro-1-(2-chlorophenyl)ethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine (1373492-22-8) + diethyl malonate (105-53-3) → 2-((2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)ethyl)malonic acid diethyl ester (1373492-23-9)

Guidance literature:

diethyl malonate; With ethanol; sodium; at 20 ℃; for 0.0833333h; Inert atmosphere;

5-(2-chloro-1-(2-chlorophenyl)ethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine; In ethanol; for 2h; Reflux;

Reference yield:

clopidogrel bisulfate (135046-48-9,120202-71-3,144077-07-6) → 2-((2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)ethyl)malonic acid diethyl ester (1373492-23-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / water

1.2: Inert atmosphere; Reflux

1.3: pH 7

2.1: thionyl chloride / tetrahydrofuran / 20 °C

2.2: pH 7

3.1: ethanol; sodium / 0.08 h / 20 °C / Inert atmosphere

3.2: 2 h / Reflux

With thionyl chloride; ethanol; sodium; sodium hydrogencarbonate; In tetrahydrofuran; water;

Reference yield:

2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanol (1373491-50-9) → 2-((2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)ethyl)malonic acid diethyl ester (1373492-23-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: thionyl chloride / tetrahydrofuran / 20 °C

1.2: pH 7

2.1: ethanol; sodium / 0.08 h / 20 °C / Inert atmosphere

2.2: 2 h / Reflux

With thionyl chloride; ethanol; sodium; In tetrahydrofuran;

upstream raw materials:

5-(2-chloro-1-(2-chlorophenyl)ethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

diethyl malonate

clopidogrel bisulfate

2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanol

Downstream raw materials:

4-(2-chlorophenyl)-4-(6,7-dihydro-4H-thieno[3,2-c]pyridine-5-yl)butyric acid ethyl ester

4-(2-chlorophenyl)-4-(6,7-dihydro-4H-thieno[3,2-c]pyridine-5-yl)butan-1-ol

Refernces