5-N-PROPYLURACIL

Base Information

• Chemical Name: 5-N-PROPYLURACIL
• CAS No.: 19030-75-2
• Molecular Formula: C₇H₁₀N₂O₂
• Molecular Weight: 154.169
• Hs Code.: 29335990
• Mol file: 19030-75-2.mol

Synonyms:Uracil,5-propyl- (8CI);5-Propyl-2,4(1H,3H)-pyrimidinedione;

Chemical Property of 5-N-PROPYLURACIL

Chemical Property:

• Melting Point: 296-298 °C
• Refractive Index: 1.481
• PKA: 9.24±0.10(Predicted)
• PSA: 65.72000
• Density: 1.126 g/cm³
• LogP: 0.01570
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

5-N-Propyluracil >95% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-N-PROPYLURACIL

There total 2 articles about 5-N-PROPYLURACIL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl n-valerate (539-82-2) + formic acid ethyl ester (109-94-4) → 5-propyluracil (19030-75-2)

Guidance literature:

With diethyl ether; sodium; Erwaermen des Reaktionsprodukts mit Harnstoff in Aethanol;

Reference yield:

→ 5-propyluracil (19030-75-2)

Guidance literature:

DOI:10.1055/s-1974-23349 DOI:10.1248/cpb.18.261

Reference yield:

5-propyluracil (19030-75-2) → 2',3',5'-tri-O-benzoyl-5-n-propyluridine (72503-96-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Me₃SiCl / Heating

2.1: SnCl₄ / 1,2-dichloro-ethane

2.2: aq. NaHCO₃

With chloro-trimethyl-silane; tin(IV) chloride; In 1,2-dichloro-ethane; 1.1: silylation / 2.1: Condensation / 2.2: Hydrolysis;

DOI:10.1016/S0223-5234(99)00211-1

upstream raw materials:

ethyl n-valerate

formic acid ethyl ester

Downstream raw materials:

2',3',5'-tri-O-benzoyl-5-n-propyluridine

3-Benzyl-5-propyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrimidine-2,4-dione

1,N⁴-dimethyl-5-propylcytosine

2,4-Diethoxy-5-propyl-pyrimidine

Refernces

• 1、 -. "4'-substituted nucleosides". . . Retrieved 2008/06/13.